| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ZIN; PPP2R6C; zinedin |
| Entrez GeneID | 29888 |
| WB Predicted band size | Calculated MW: 81 kDa; Observed MW: 81 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human Striatin 4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Striatin 4(STRN4)抗体的3篇参考文献示例(人工整理，非真实文献，仅供格式参考)：
1. **标题**：*"Characterization of Striatin 4 antibody for detecting protein-protein interactions in neuronal signaling pathways"*
**作者**：Smith J, et al.
**摘要**：研究报道了一种特异性识别Striatin 4(STRN4)的多克隆抗体的开发，通过免疫沉淀和免疫荧光验证其在检测STRN4与PP2A磷酸酶复合物相互作用中的应用。
2. **标题**：*"Striatin 4 regulates endothelial cell polarity via antibody-validated membrane localization"*
**作者**：Lee S, et al.
**摘要**：利用商业化Striatin 4单克隆抗体，揭示了STRN4在血管内皮细胞极性形成中的作用，证实其通过膜定位调控细胞骨架重排。
3. **标题**：*"A novel monoclonal antibody against Striatin 4 reveals its tumor-suppressive role in glioblastoma"*
**作者**：Wang H, et al.
**摘要**：开发了一种高特异性抗STRN4单克隆抗体，并通过Western blot和免疫组化证明STRN4在胶质母细胞瘤中低表达，提示其抑癌潜力。
(注：以上文献为示例，实际引用需检索PubMed或相关数据库获取真实研究。)
Striatin 4 (STRN4) is a member of the striatin family of scaffolding proteins, which includes STRN, STRN3. and STRN4. These proteins are characterized by multiple interaction domains, including coiled-coil motifs, WD-repeat regions, and caveolin-binding domains, enabling them to assemble large protein complexes. Striatins are integral components of the STRIPAK (Striatin-interacting phosphatase and kinase) complex, which regulates diverse cellular processes such as signal transduction, cell cycle progression, cytoskeletal organization, and vesicular trafficking. STRN4. specifically, is expressed in various tissues, with notable roles in neuronal and endocrine systems, though its functions are less well-characterized compared to other family members.
Antibodies targeting STRN4 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate STRN4’s involvement in cellular signaling pathways and disease contexts. For example, STRN4 has been implicated in cancer progression, where dysregulated STRIPAK complexes may promote tumorigenesis via altered kinase/phosphatase activity. Additionally, STRN4 antibodies aid in exploring its role in neurological disorders and metabolic regulation, given its interaction with proteins linked to insulin signaling and synaptic plasticity. Validated antibodies are crucial for specificity, as striatin family members share structural homology, requiring careful validation using knockout controls or epitope mapping. Research utilizing STRN4 antibodies continues to uncover its contributions to cellular homeostasis and pathophysiology.
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