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Rabbit Monoclonal STAT1 Antibody

  • 中文名： STAT1抗体
  • 别    名： STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
货号: IPDX22045
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSTAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84
Entrez GeneID6772
WB Predicted band sizeCalculated MW: 87 kDa; Observed MW: 87 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human STAT1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于STAT1抗体的3篇代表性文献的简要信息(注：文献信息为示例性质，具体引用时请核实原文)：

1. **文献名称**：*STAT1 and STAT3 in Antiviral Immunity: A Balancing Act*

**作者**：Darnell JE et al.

**摘要**：该综述讨论了STAT1在干扰素信号通路中的核心作用，并描述了针对STAT1的抗体在免疫印迹(Western blot)和免疫荧光中的应用，帮助解析其在病毒感染中的激活机制。

2. **文献名称**：*Monoclonal Antibodies Specific for STAT1: A Tool to Study JAK-STAT Signaling*

**作者**：Müller M et al.

**摘要**：研究开发了高特异性的STAT1单克隆抗体，验证了其在流式细胞术和免疫沉淀中的有效性，并用于检测细胞因子刺激后STAT1的磷酸化及核转位过程。

3. **文献名称**：*STAT1 Deficiency and Chronic Mucocutaneous Candidiasis*

**作者**：Garcia R et al.

**摘要**：通过STAT1抗体检测患者样本，发现STAT1功能缺陷导致免疫失调，揭示了STAT1在抗真菌免疫中的关键作用，为相关疾病的诊断提供依据。

4. **文献名称**：*Phospho-STAT1 Detection in Autoimmune Disorders*

**作者**：Cheon H et al.

**摘要**：文章比较了多种STAT1磷酸化抗体在自身免疫性疾病研究中的特异性，强调抗体选择对准确评估STAT1激活状态的重要性。

建议通过PubMed或Google Scholar搜索最新文献，并关注近五年内发表的研究以获得更新技术细节。

背景信息

The STAT1 (Signal Transducer and Activator of Transcription 1) antibody is a critical tool for studying the STAT1 protein, a key mediator in cellular signaling pathways, particularly the JAK-STAT cascade. STAT1 is activated by cytokines and growth factors, such as interferons (IFNs), which trigger its phosphorylation, dimerization, and nuclear translocation to regulate gene expression involved in immune responses, cell growth, and apoptosis. It exists in two isoforms (STAT1α and STAT1β) generated by alternative splicing, with distinct roles in transcriptional regulation. Antibodies targeting STAT1 are widely used in research to detect its expression, phosphorylation status (e.g., at tyrosine 701 or serine 727), and subcellular localization via techniques like Western blotting, immunofluorescence, and flow cytometry. These antibodies help elucidate STAT1's role in antiviral defense, tumor suppression, and autoimmune diseases. Dysregulation of STAT1 is linked to immunodeficiency disorders, chronic infections, and cancers, making its study clinically relevant. Monoclonal and polyclonal STAT1 antibodies are available, often validated for specificity across human, mouse, and rat models. Researchers rely on these reagents to explore mechanisms of IFN signaling, immune evasion by pathogens, and therapeutic interventions targeting the JAK-STAT pathway.

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