| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADIP; hMsd1 |
| Entrez GeneID | 117178 |
| WB Predicted band size | Calculated MW: 71 kDa; Observed MW: 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human SSX2IP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于SSX2IP抗体的示例参考文献(内容为模拟示例，建议通过学术数据库核实最新文献)：
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1. **文献名称**: "SSX2IP interacts with the Aurora A kinase and promotes centrosome maturation"
**作者**: Yan, K., et al.
**摘要**: 本研究揭示了SSX2IP蛋白通过与Aurora A激酶相互作用调控中心体成熟的机制。作者使用特异性SSX2IP抗体进行免疫荧光和免疫共沉淀实验，证实其在有丝分裂中的定位及功能。
2. **文献名称**: "SSX gene family expression in human cancers: immunohistochemical analysis using a novel monoclonal antibody against SSX2IP"
**作者**: Gure, A.O., et al.
**摘要**: 研究开发了一种针对SSX2IP的单克隆抗体，并通过免疫组化分析其在多种肿瘤组织中的表达模式，发现SSX2IP在黑色素瘤和肺癌中显著高表达。
3. **文献名称**: "The role of SSX2IP in neuronal migration and cortical development"
**作者**: Smith, J., et al.
**摘要**: 利用SSX2IP抗体进行Western blot和免疫染色，发现SSX2IP通过调控微管动力学影响神经元迁移，其缺失导致小鼠皮层发育异常。
4. **文献名称**: "Characterization of a polyclonal antibody against SSX2IP and its application in protein interaction studies"
**作者**: Lee, H., et al.
**摘要**: 文章描述了一种兔源多克隆抗体的制备与验证，证明其可用于检测内源性SSX2IP蛋白，并用于探索其与MAP1B等微管相关蛋白的相互作用。
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**注意**：以上文献信息为模拟示例，实际研究中请通过PubMed、Web of Science等平台检索最新文献。若需具体文章，可提供更详细的研究背景或关键词进一步筛选。
The SSX2IP (Synovial Sarcoma X Breakpoint 2 Interacting Protein) antibody targets a protein involved in cell division and cancer progression. SSX2IP, also called Astrin, plays a critical role in mitotic spindle formation, chromosome segregation, and kinetochore-microtubule interactions. It interacts with components like SKAP and dynein to ensure proper chromosome alignment and segregation during mitosis. Dysregulation of SSX2IP is linked to genomic instability and cancer development, with overexpression observed in malignancies such as hepatocellular carcinoma, melanoma, and acute myeloid leukemia. Its oncogenic potential and association with tumor aggressiveness make it a biomarker of interest in cancer research.
SSX2IP antibodies are widely used to study protein expression, localization, and functional mechanisms in cellular models. These antibodies (polyclonal or monoclonal, often raised in rabbits or mice) enable techniques like Western blotting, immunofluorescence, and immunohistochemistry. Validation typically includes testing in SSX2IP-knockdown or knockout cell lines to confirm specificity. Commercially available from suppliers like Abcam and Cell Signaling Technology, these tools support research in cancer biology, cell cycle regulation, and therapeutic target discovery. Recent studies also explore SSX2IP's role beyond mitosis, including centrosome integrity and immune modulation, highlighting its multifaceted cellular roles.
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