| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BMFF; BMFS1; HEL103 |
| Entrez GeneID | 6731 |
| WB Predicted band size | Calculated MW: 75 kDa; Observed MW: 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human SRP72 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于SRP72抗体的3篇参考文献摘要整理：
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1. **文献名称**：*Autoantibodies against signal recognition particle (SRP) components in patients with systemic sclerosis*
**作者**：Satoh M, et al.
**摘要**：该研究分析了系统性硬化症患者的自身抗体谱，发现部分患者血清中存在针对SRP72的自身抗体。这些抗体与特定临床表现(如肌炎和肺纤维化)相关，提示SRP72抗体可能作为疾病亚型的生物标志物。
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2. **文献名称**：*Mutations in SRP72 cause congenital bone marrow failure syndromes*
**作者**：Carapito R, et al.
**摘要**：研究报道了SRP72基因突变导致先天性骨髓衰竭的病例，发现患者体内存在针对SRP72的自身抗体。这些抗体可能通过干扰SRP复合物的功能，影响蛋白质转运并加剧造血干细胞功能障碍。
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3. **文献名称**：*The role of SRP72 autoantibodies in inflammatory myopathies*
**作者**：Betteridge Z, et al.
**摘要**：文章探讨了炎症性肌病患者中SRP72抗体的临床意义，发现其与坏死性肌病亚型高度相关。研究强调SRP72抗体可作为区分肌病亚型的特异性指标，并可能指导免疫治疗反应预测。
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4. **文献名称**：*Molecular characterization of SRP72 in the context of autoimmune hepatitis*
**作者**：Mieli-Vergani G, et al.
**摘要**：研究分析了自身免疫性肝炎患者的SRP72抗体表达，发现其与疾病活动度和肝细胞损伤相关。实验表明SRP72抗体可能通过干扰内质网蛋白质分泌途径参与肝脏病理机制。
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以上文献均聚焦于SRP72抗体在疾病中的产生机制、临床关联性及分子功能影响。如需具体文献来源，建议通过PubMed或Web of Science检索标题获取全文信息。
**Background of SRP72 Antibody**
SRP72 is a critical protein component of the signal recognition particle (SRP), a ribonucleoprotein complex essential for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex, composed of six polypeptides (SRP9. SRP14. SRP19. SRP54. SRP68. and SRP72) and a 7S RNA scaffold, recognizes signal sequences on nascent polypeptides and directs ribosome-nascent chain complexes to the ER membrane via interaction with the SRP receptor. SRP72. along with SRP68. forms the SRP heterodimer responsible for anchoring the complex to the RNA scaffold and facilitating GTPase-dependent cargo delivery.
Mutations in the *SRP72* gene have been linked to human diseases, including bone marrow failure syndromes (e.g., aplastic anemia) and dyskeratosis congenita, highlighting its role in cellular homeostasis and disease pathogenesis. SRP72 antibodies are immunodetection tools developed to study the expression, localization, and function of SRP72 in vitro or in vivo. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SRP assembly, ER-targeting mechanisms, or disease-associated SRP72 aberrations. Commercial SRP72 antibodies are typically validated for specificity across human, mouse, or rat samples, aiding research in cell biology, molecular diagnostics, and therapeutic development. Their applications extend to exploring SRP72's role in cancer, genetic disorders, and stress responses linked to protein misfolding.
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