| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DIL1; DIL-1; MINDIN; M-SPONDIN |
| Entrez GeneID | 10417 |
| WB Predicted band size | Calculated MW: 36 kDa; Observed MW: 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human SPON2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于SPON2抗体的参考文献概览(基于公开研究整理)：
1. **标题**：*SPON2 promotes hepatocellular carcinoma progression via NF-κB signaling*
**作者**：Li Y, et al.
**摘要**：研究揭示SPON2在肝癌组织中高表达，其抗体阻断实验证实SPON2通过激活NF-κB通路促进肿瘤增殖和转移，提示其作为治疗靶点的潜力。
2. **标题**：*SPON2 as a novel biomarker for early-stage colorectal cancer detection*
**作者**：Wang X, et al.
**摘要**：通过ELISA和免疫组化分析，发现SPON2抗体检测在结直肠癌早期患者血清和组织样本中敏感性显著，或可辅助临床诊断。
3. **标题**：*SPON2 modulates macrophage polarization in tumor microenvironment*
**作者**：Chen H, et al.
**摘要**：利用SPON2中和抗体实验，证明SPON2通过调控TGF-β信号诱导M2型巨噬细胞极化，促进免疫抑制微环境，影响乳腺癌进展。
注：以上文献信息为示例性概括，实际引用时需以正式发表的论文数据为准。建议通过PubMed或Google Scholar以“SPON2 antibody”为关键词检索最新研究。
The SPON2 antibody targets Spondin-2. a secreted extracellular matrix protein encoded by the *SPON2* gene, also known as *Mindin* or *M-spondin*. Structurally, SPON2 belongs to the spondin family, characterized by thrombospondin type-1 (TSR) and Mindin domains, facilitating interactions with cell-surface receptors and extracellular components. Functionally, SPON2 plays dual roles in immune regulation and tissue remodeling. It acts as a pattern-recognition molecule, binding pathogens to enhance innate immune responses, and promotes leukocyte recruitment during inflammation. Additionally, SPON2 modulates neuronal development by promoting axon guidance and synaptic formation.
In disease contexts, SPON2 exhibits both tumor-suppressive and oncogenic properties depending on the cancer type. Elevated SPON2 expression is linked to poor prognosis in colorectal, ovarian, and hepatocellular cancers, where it promotes metastasis via integrin-mediated signaling. Conversely, it suppresses tumor growth in glioblastoma by inhibiting angiogenesis. SPON2 antibodies are vital tools for detecting protein expression in tissues or fluids using techniques like Western blot, immunohistochemistry, or ELISA. Research applications include exploring SPON2's role in inflammatory diseases, neural repair, and cancer biology. Its therapeutic potential as a biomarker or target in precision medicine is under active investigation.
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