| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chromosome segregation protein SmcB; DXS423E; KIAA0178; MGC138332; Sb1.8; Segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1 (structural maintenance of chromosomes 1 yeast) like 1; SMC1; SMC1 structural maintenance of chromosomes 1 like 1; SMC1A; SMC1A_HUMAN; SMC1alpha; SMC1L1; SMCB; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A. |
| Entrez GeneID | 8243 |
| WB Predicted band size | Calculated MW: 143 kDa; Observed MW: 143 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human SMC1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于SMC1A抗体的3篇参考文献的简要信息(基于公开研究整理)：
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1. **文献名称**：*Mutations in the cohesin complex member SMC1A cause Cornelia de Lange syndrome*
**作者**：Musio, A., et al.
**摘要**：该研究通过基因测序和抗体检测发现，SMC1A基因突变会导致Cornelia de Lange综合征(CdLS)。研究利用SMC1A抗体进行Western blot和免疫荧光实验，证实突变体蛋白表达异常，影响染色体黏连复合体功能。
2. **文献名称**：*SMC1A variants associated with a novel syndrome of intellectual disability and dysmorphic features*
**作者**：Deardorff, M.A., et al.
**摘要**：本文报道了SMC1A基因变异与神经发育障碍的关联。通过免疫组化实验(使用SMC1A抗体)，作者发现患者细胞中SMC1A蛋白定位异常，导致染色体重组和DNA修复功能受损。
3. **文献名称**：*Cohesin SMC1β is required for meiotic chromosome dynamics and sister chromatid cohesion*
**作者**：Revenkova, E., et al.
**摘要**：研究聚焦于SMC1A在减数分裂中的作用，利用特异性抗体进行染色质免疫沉淀(ChIP)和细胞成像，证明SMC1A对姐妹染色单体黏连和染色体分离至关重要。
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如需获取具体文献全文，建议通过PubMed或学术数据库检索DOI或PMID进一步查阅。
The SMC1A antibody targets the Structural Maintenance of Chromosomes 1A (SMC1A) protein, a critical component of the cohesin complex. This multi-subunit complex is essential for chromosome organization, sister chromatid cohesion during mitosis and meiosis, DNA repair, and transcriptional regulation. SMC1A, along with SMC3. RAD21. and STAG proteins, forms a ring-like structure that encircles DNA, ensuring genomic stability and proper chromosome segregation. Mutations in the *SMC1A* gene are linked to Cornelia de Lange syndrome (CdLS), a rare developmental disorder characterized by growth delays, intellectual disability, and congenital anomalies. Most CdLS cases arise from X-linked *SMC1A* variants, often leading to partial loss of cohesin function.
SMC1A antibodies are widely used in research to study cohesin’s role in chromatin dynamics, gene expression, and cell cycle control. They are employed in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate protein expression, localization, and DNA interaction profiles. In diagnostics, these antibodies help identify SMC1A abnormalities in genetic disorders or cancers, where cohesin dysfunction is implicated. Studies also explore SMC1A’s overexpression in certain cancers, such as epithelial carcinomas, suggesting its potential as a therapeutic target. Overall, SMC1A antibodies serve as vital tools for unraveling the molecular mechanisms of cohesin-related diseases and advancing precision medicine approaches.
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