| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BAF155; CRACC1; Rsc8; SMARCC1; SRG3; SWI3 |
| Entrez GeneID | 6599 |
| WB Predicted band size | Calculated MW: 123 kDa; Observed MW: 155 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human SMARCC1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于SMARCC1抗体的3篇参考文献示例(注：文献为假设性示例，实际引用请根据真实文献调整)：
---
1. **文献名称**: "SMARCC1 is essential for the assembly and integrity of the SWI/SNF chromatin remodeling complex"
**作者**: Kadoch C, Crabtree GR
**摘要**: 本研究通过免疫共沉淀(Co-IP)和Western blot技术，使用SMARCC1抗体验证其在SWI/SNF复合体中的核心作用，发现SMARCC1缺失导致复合体结构破坏，进而影响染色质重塑和基因表达调控。
2. **文献名称**: "SMARCC1 expression correlates with tumor suppression in colorectal cancer"
**作者**: Wang X, et al.
**摘要**: 通过免疫组化(IHC)和Western blot分析SMARCC1抗体标记的肿瘤组织样本，发现SMARCC1低表达与结直肠癌进展和不良预后显著相关，提示其作为抑癌因子的潜在作用。
3. **文献名称**: "Functional characterization of SMARCC1 in neural stem cell differentiation"
**作者**: Smith J, Doe RP
**摘要**: 利用SMARCC1抗体进行ChIP-seq和敲低实验，揭示SMARCC1通过调控神经分化相关基因的染色质可及性，影响神经干细胞的命运决定。
---
如需真实文献，建议在PubMed或Google Scholar中搜索关键词“SMARCC1 antibody”或“SMARCC1 SWI/SNF”，并筛选涉及抗体应用的实验研究。
SMARCC1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1), also known as BAF155. is a core subunit of the SWI/SNF (BAF) chromatin remodeling complex. This evolutionarily conserved multi-protein complex utilizes ATP to modulate chromatin structure, enabling transcriptional regulation, DNA repair, and cellular differentiation. SMARCC1 plays a structural and functional role in stabilizing the SWI/SNF complex and mediating interactions with transcription factors or epigenetic modifiers. It is broadly expressed across tissues and essential for embryonic development, stem cell maintenance, and tissue-specific gene expression programs.
Antibodies targeting SMARCC1 are widely used to study SWI/SNF complex composition, localization, and molecular mechanisms in diseases. Over 20% of human cancers harbor SWI/SNF mutations, making SMARCC1 a biomarker in oncology research. These antibodies are applied in techniques like Western blotting, immunoprecipitation, immunofluorescence, and ChIP-seq to investigate SMARCC1's role in gene regulation, cancer progression, and developmental disorders. Commercially available clones (e.g., D7F5S from Cell Signaling Technology, EPR17766 from Abcam) are typically validated in knockout controls to ensure specificity. Recent studies also explore SMARCC1 dysregulation in neurological conditions and viral pathogenesis, highlighting its broad relevance in chromatin biology and disease mechanisms.
×
