| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | VGR; VGR1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human BMP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SNX9抗体的3篇代表性文献，供参考：
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1. **"SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin"**
*作者*: Yarar D. et al.
*摘要*：研究利用SNX9抗体进行免疫共沉淀和免疫荧光实验，揭示了SNX9通过结合动力蛋白(dynamin)和肌动蛋白，调控细胞膜内陷过程，促进网格蛋白介导的内吞作用。
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2. **"Sorting nexin 9 facilitates clathrin-coated pit assembly via its interaction with AP-2"**
*作者*: Soulet F. et al.
*摘要*：通过Western blot和免疫染色实验，发现SNX9抗体可特异性识别细胞内的SNX9蛋白，并证明其通过与AP-2复合物结合，促进网格蛋白包被小窝的组装。
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3. **"SNX9 couples actin assembly to phosphoinositide signals in clathrin-mediated endocytosis"**
*作者*: Shin N. et al.
*摘要*：利用SNX9抗体研究其亚细胞定位，发现SNX9通过磷酸肌醇信号通路协调肌动蛋白重塑与内吞作用，为膜变形提供机械力支持。
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如需具体文献来源或更多研究，建议通过PubMed或Google Scholar检索标题关键词。
SNX9 (Sorting Nexin 9) is a multidomain protein belonging to the sorting nexin family, which plays critical roles in membrane remodeling, endocytosis, and intracellular trafficking. It contains a Phox homology (PX) domain for phosphoinositide binding, a Bin-Amphiphysin-Rvs (BAR) domain for sensing and inducing membrane curvature, and an Src homology 3 (SH3) domain for interacting with dynamin and other proteins involved in vesicle scission. SNX9 is essential for clathrin-mediated endocytosis, where it coordinates membrane deformation with actin dynamics and cargo recruitment.
Antibodies targeting SNX9 are widely used in research to study its expression, localization, and function in cellular processes. These antibodies enable techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping to elucidate SNX9's involvement in physiological and pathological contexts, such as cancer metastasis, neuronal development, and receptor signaling. SNX9 dysregulation has been linked to diseases like Alzheimer's and cancer, making its study therapeutically relevant.
SNX9 antibodies are typically validated for specificity across species (human, mouse, rat) and applications. They aid in identifying SNX9's interaction partners and post-translational modifications, offering insights into its regulatory mechanisms. As a versatile molecular tool, SNX9 antibodies continue to advance our understanding of endocytic pathways and their broader implications in cellular homeostasis.
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