| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HI95; SES2; SEST2 |
| Entrez GeneID | 83667 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human SESN2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是关于SESN2(Sestrin2)抗体的3篇参考文献，涵盖其在不同疾病模型中的应用及机制研究：
---
1. **文献名称**：*Sestrin2 as a Novel Biomarker and Therapeutic Target in Various Diseases*
**作者**：Lee JH, et al.
**摘要**：本文系统综述了SESN2在氧化应激、代谢紊乱和癌症中的生物学功能，重点讨论了使用SESN2抗体通过Western blot和免疫组化技术检测其在肝细胞癌组织中的表达上调，及其与mTORC1信号通路抑制的关联。
---
2. **文献名称**：*Sestrin2 modulates AMPK/mTOR signaling in cardiac ischemia-reperfusion injury*
**作者**：Zhang Y, et al.
**摘要**：研究利用SESN2特异性抗体，在小鼠心肌缺血再灌注模型中验证SESN2通过激活AMPK通路减轻氧化损伤。实验显示，SESN2抗体检测到其在心肌细胞中的表达水平与细胞凋亡呈负相关。
---
3. **文献名称**：*The role of Sestrin2 in regulating autophagy in Alzheimer's disease models*
**作者**：Kim M, et al.
**摘要**：通过免疫荧光和ELISA技术，结合SESN2抗体，研究发现阿尔茨海默病小鼠脑组织中SESN2表达显著降低，导致自噬功能障碍。该研究提示SESN2可能作为神经退行性疾病的潜在治疗靶点。
---
**备注**：以上文献为示例性质，实际引用时需根据具体研究补充完整信息(期刊、年份、DOI等)。若需全文或更多细节，建议通过PubMed或ResearchGate等平台检索关键词"Sestrin2 antibody"+"应用方向(如癌症、代谢疾病等)"。
Sestrin2 (SESN2) is a stress-inducible protein belonging to the Sestrin family, known for its critical role in cellular responses to oxidative stress, DNA damage, and hypoxia. It functions as a redox sensor and regulates metabolic homeostasis by modulating AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) pathways, thereby influencing autophagy, antioxidant defense, and cell survival. SESN2 expression is upregulated under stress conditions, such as oxidative or genotoxic insults, through transcription factors like p53 and nuclear factor erythroid 2-related factor 2 (NRF2).
SESN2 antibodies are essential tools for detecting and quantifying SESN2 protein levels in research settings, enabling studies on its regulatory mechanisms and involvement in diseases like cancer, neurodegenerative disorders, and metabolic syndromes. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore SESN2's tissue-specific expression, subcellular localization, and interactions with signaling molecules. Recent studies highlight SESN2's dual role as both a tumor suppressor and a potential therapeutic target, given its context-dependent effects on apoptosis and proliferation. However, antibody specificity remains a consideration, necessitating validation via knockout controls or peptide-blocking assays. Ongoing research aims to elucidate SESN2's therapeutic potential in modulating oxidative stress and aging-related pathologies.
×
