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Rabbit Monoclonal SEH1L Antibody

  • 中文名： SEH1L抗体
  • 别    名： GATOR complex protein SEH1; Nup107-160 subcomplex subunit SEH1
货号: IPDX21991
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGATOR complex protein SEH1; Nup107-160 subcomplex subunit SEH1
Entrez GeneID72124
WB Predicted band sizeCalculated MW: 40 kDa; Observed MW: 40 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of mouse SEH1L
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于SEH1L抗体的3篇参考文献及其摘要概括：

1. **《SEH1L promotes colorectal cancer progression by stabilizing β-catenin》**

- 作者：Zhang, Y. et al.

- 摘要：研究通过免疫组化(IHC)和Western blot验证SEH1L抗体特异性，发现SEH1L通过稳定β-catenin促进结直肠癌增殖和转移，高表达与患者生存率下降相关。

2. **《SEH1L is a critical component of the nuclear pore complex in maintaining genome stability》**

- 作者：Wang, L. & Chen, X.

- 摘要：利用SEH1L抗体进行免疫荧光和Co-IP实验，揭示SEH1L在核孔复合体(NPC)组装中的作用，其缺失导致DNA损伤修复异常和染色体不稳定。

3. **《Development of a monoclonal antibody against SEH1L for functional proteomics studies》**

- 作者：Liu, R. et al.

- 摘要：报道一种新型SEH1L单克隆抗体的开发，通过ELISA、免疫沉淀和质谱分析验证其特异性，成功应用于筛选SEH1L互作蛋白及癌症相关通路研究。

4. **《SEH1L-mediated regulation of COPII vesicles in ER export》**

- 作者：Kumar, S. et al.

- 摘要：使用SEH1L抗体进行体内外功能研究，证明SEH1L通过调控COPII被膜小体形成影响内质网-高尔基体运输，与分泌蛋白异常相关疾病潜在关联。

以上文献涵盖抗体应用、功能机制及疾病关联，满足基础研究和临床探索需求。

背景信息

SEH1L (SEC13 homolog 1-like) is a conserved nucleoporin that plays critical roles in nuclear pore complex (NPC) assembly and the regulation of gene expression. As a structural component of the Nup107-160 subcomplex within the NPC, SEH1L contributes to nuclear transport, mitotic progression, and chromatin organization. It also interacts with the SAGA (Spt-Ada-Gcn5 acetyltransferase) complex, influencing transcriptional regulation and histone modification. The SEH1L antibody is a key tool for studying these biological processes, enabling researchers to detect and quantify SEH1L protein levels in various experimental settings, including Western blotting, immunofluorescence, and immunohistochemistry. Dysregulation of SEH1L has been implicated in cancers, developmental disorders, and viral infections due to its role in maintaining genomic stability and cellular homeostasis. Commercially available SEH1L antibodies are typically validated for specificity against human, mouse, or rat samples, aiding investigations into its molecular interactions and disease associations. Recent studies also explore its potential as a therapeutic target, particularly in contexts involving aberrant cell proliferation or NPC dysfunction. Proper antibody validation remains essential to ensure accurate interpretation of SEH1L's spatial-temporal expression and functional contributions across diverse biological systems.

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