| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SCD1; FADS5; SCDOS; MSTP008 |
| Entrez GeneID | 6319 |
| WB Predicted band size | Calculated MW: 42 kDa; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human SCD1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于SCD1抗体的3篇文献示例(内容基于典型研究方向概括，非真实文献)：
1. **"SCD1 overexpression promotes lipid droplet formation in hepatocellular carcinoma"**
- **作者**: Zhang Y, et al.
- **摘要**: 研究利用SCD1抗体通过免疫组化分析肝癌组织，发现SCD1高表达与脂滴积累和肿瘤进展相关，提示其作为潜在治疗靶点。
2. **"Anti-SCD1 monoclonal antibody inhibits adipogenesis in vitro"**
- **作者**: Smith RJ, et al.
- **摘要**: 开发了一种特异性SCD1单克隆抗体，证实其通过阻断酶活性抑制3T3-L1前脂肪细胞分化，为代谢性疾病治疗提供新策略。
3. **"SCD1 antibody-based detection in obesity-associated breast cancer models"**
- **作者**: Lee H, et al.
- **摘要**: 采用SCD1抗体进行Western blot和免疫荧光检测，证明肥胖小鼠乳腺癌模型中SCD1表达上调与肿瘤侵袭性增强相关。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索确认。)
Stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in lipid metabolism, catalyzing the conversion of saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) by introducing a double bond in the Δ9 position. This process is critical for maintaining membrane fluidity, regulating metabolic homeostasis, and synthesizing signaling molecules. SCD1 is highly expressed in lipogenic tissues such as the liver, adipose tissue, and mammary glands. Dysregulation of SCD1 has been implicated in metabolic disorders (e.g., obesity, insulin resistance), cancer progression, and inflammatory diseases, making it a therapeutic target of interest.
SCD1 antibodies are immunological tools designed to detect and quantify SCD1 protein levels in research applications. These antibodies enable the study of SCD1 expression patterns, cellular localization, and regulatory mechanisms across experimental models, including cell lines, animal tissues, and clinical samples. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available SCD1 antibodies are typically raised against specific epitopes of human or murine SCD1. with validation across species (e.g., human, mouse, rat) to ensure cross-reactivity. Recent studies using SCD1 antibodies have highlighted its role in tumor lipid metabolism, chemoresistance, and crosstalk with oncogenic pathways, reinforcing its potential as a biomarker or drug target. However, variability in antibody specificity and batch consistency remains a challenge, necessitating rigorous validation for experimental reproducibility.
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