| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 797; Zinc finger protein SALL4 |
| Entrez GeneID | 57167 |
| WB Predicted band size | Calculated MW: 112 kDa; Observed MW: 112 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human Sall4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于SALL4抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库核实)：
1. **"SALL4 as a Diagnostic Marker for Germ Cell Tumors"**
- **作者**: Zhang JJ, et al.
- **摘要**: 研究验证了SALL4抗体在生殖细胞肿瘤(如卵黄囊瘤、精原细胞瘤)中的高表达，提出其可作为鉴别诊断的敏感标志物，尤其在转移性病例中具有重要价值。
2. **"SALL4 Expression in Acute Myeloid Leukemia"**
- **作者**: Weng A, et al.
- **摘要**: 分析了SALL4抗体在急性髓系白血病(AML)患者骨髓样本中的表达，发现其与特定亚型(如M0/M1)相关，可能参与白血病干细胞自我更新通路。
3. **"Prognostic Significance of SALL4 in Hepatocellular Carcinoma"**
- **作者**: Matsuura K, et al.
- **摘要**: 通过免疫组化研究发现，SALL4在肝细胞癌中异常表达，且与肿瘤分化程度及患者预后不良显著相关，提示其可作为潜在预后标志物。
4. **"SALL4 Antibody in Stem Cell Research"**
- **作者**: Cao D, et al.
- **摘要**: 探讨了SALL4抗体在胚胎干细胞和多能干细胞中的染色应用，证实其在维持干细胞多能性和分化调控中的关键作用。
**建议**：可通过PubMed或Google Scholar搜索关键词“SALL4 antibody”、“diagnostic application”或“cancer biomarkers”获取真实文献。
The Sall4 antibody is a crucial tool in molecular biology and pathology for detecting Sall4. a transcription factor belonging to the Spalt-like (SALL) family. Sall4 plays a vital role in embryonic development, particularly in maintaining pluripotency of stem cells and regulating organogenesis. It contains zinc finger domains, enabling DNA binding and interaction with chromatin modifiers, often acting as a transcriptional repressor. The gene encoding Sall4 is located on human chromosome 20q13.2. a region occasionally amplified in cancers.
Sall4 antibodies are widely used in research and diagnostics to identify tissues or cancers with aberrant Sall4 expression. In pathology, Sall4 immunohistochemistry is a key marker for germ cell tumors (e.g., seminomas, yolk sac tumors) and certain carcinomas, such as subsets of gastric, lung, or ovarian cancers. It also aids in diagnosing acute myeloid leukemia (AML) with specific genetic abnormalities. In research, Sall4 antibodies help study pluripotent stem cells, organ development, and cancer mechanisms, particularly in contexts of metastasis and therapy resistance.
Most Sall4 antibodies are monoclonal, targeting specific epitopes (e.g., N-terminal regions). Validation using positive/negative controls is essential due to potential cross-reactivity with other SALL proteins. Its expression in healthy adult tissues is typically restricted, making it a valuable diagnostic marker when detected abnormally. Ongoing studies explore Sall4's role in regenerative medicine and as a therapeutic target in cancers.
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