| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 18A2; 42A; calcium Placental protein; Calvasculin; CAPL; Fibroblast specific protein 1; Fibroblast specific protein; FSP1; Leukemia multidrug resistance associated protein; Malignant transformation suppression 1; Metastasin; MTS1; OTTHUMP00000015467; OTTHUMP00000015468; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100 A4; Protein S100-A4; S100 calcium binding protein A4 (calcium protein; calvasculin; metastasin; murine placental homolog); S100 calcium binding protein A4; S100 calcium-binding protein A4; S100a4; S10A4_HUMAN. |
| Entrez GeneID | 6275 |
| WB Predicted band size | Calculated MW: 12 kDa; Observed MW: 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human S100A4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于S100A4抗体的3篇参考文献示例(简要概括)：
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1. **文献名称**：*S100A4 antibody suppresses metastasis formation by blocking the recruitment of myeloid-derived suppressor cells*
**作者**：Garrett, S.C., et al.
**摘要**：研究利用S100A4特异性抗体在小鼠模型中抑制肿瘤转移，发现该抗体通过阻断S100A4与免疫细胞(如MDSCs)的相互作用，减少促转移微环境形成，显著降低肺转移发生率。
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2. **文献名称**：*Targeting S100A4 with antibodies improves cardiac fibrosis in experimental models*
**作者**：Schneider, M., et al.
**摘要**：该文献报道了一种人源化S100A4抗体的开发，通过中和S100A4的活性，显著减少心肌纤维化模型中的胶原沉积和成纤维细胞活化，提示其作为纤维化疾病治疗的潜在策略。
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3. **文献名称**：*S100A4 regulates macrophage activation and inflammatory response via antibody-mediated neutralization*
**作者**：Schmidt-Hansen, B., et al.
**摘要**：研究发现S100A4抗体可通过抑制S100A4与RAGE受体的结合，降低巨噬细胞的促炎因子(如TNF-α、IL-6)分泌，从而缓解慢性炎症性疾病中的组织损伤。
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**注**：以上为模拟示例，实际文献需通过PubMed或专业数据库检索。若需具体文章，建议使用关键词“S100A4 antibody”+“应用领域(如cancer/fibrosis)”筛选近年高被引论文。
S100A4. a member of the S100 calcium-binding protein family, is implicated in diverse cellular processes, including proliferation, migration, and extracellular matrix remodeling. It is encoded by the *S100A4* gene and is also known as metastasin-1 (MTS1) due to its strong association with cancer metastasis. S100A4 expression is elevated in various malignancies, such as breast, colon, and pancreatic cancers, where it promotes epithelial-mesenchymal transition (EMT), angiogenesis, and stromal interactions. Its role extends beyond oncology, involving inflammatory diseases, fibrosis, and cardiovascular disorders.
S100A4 antibodies are critical tools for detecting and analyzing the protein's expression and function in research and diagnostics. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study S100A4's localization, regulation, and interaction partners. Commercially available clones vary in host species (e.g., mouse, rabbit) and applications, requiring validation for specificity and cross-reactivity.
In clinical contexts, S100A4 antibodies aid in assessing tumor aggressiveness and patient prognosis, as high S100A4 levels often correlate with poor survival. However, challenges remain, including isoform-specific detection and distinguishing between intracellular and secreted forms. Ongoing research explores therapeutic targeting of S100A4 using neutralizing antibodies or inhibitors to block its metastasis-promoting effects.
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