| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p23 |
| Entrez GeneID | 6237 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human RRAS |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于RRAS抗体的3篇参考文献示例(内容基于学术研究领域常见方向模拟，非真实文献)：
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1. **文献名称**: *"RRAS-specific autoantibodies as potential biomarkers in colorectal cancer"*
**作者**: Smith A, et al.
**摘要**: 研究报道了在结直肠癌患者血清中检测到RRAS蛋白的自身抗体，其表达水平与肿瘤分期相关，提示RRAS抗体可能作为癌症早期诊断的血清标志物。
2. **文献名称**: *"Development of a monoclonal antibody against RRAS for functional GTPase activity analysis"*
**作者**: Lee JH, et al.
**摘要**: 文章描述了一种高特异性抗RRAS单克隆抗体的开发，该抗体可识别RRAS的活性构象(GTP结合状态)，用于研究其在细胞信号转导中的动态调控机制。
3. **文献名称**: *"Autoimmune profiling reveals RRAS antibodies in neurodegenerative disorders"*
**作者**: Gonzalez R, et al.
**摘要**: 通过系统性筛查神经退行性疾病患者样本，发现RRAS抗体与特定亚型的多系统萎缩症(MSA)存在关联，为探索自身免疫反应在神经病变中的作用提供了新线索。
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**注**：以上文献为模拟示例，实际研究中请通过PubMed、Web of Science等数据库检索真实发表的论文。如需具体文献，建议结合关键词“RRAS antibody”“RRAS autoantibody”“RRAS biomarker”进一步查询。
**Background of RRAS Antibodies**
RRAS (related RAS viral oncogene homolog) is a small GTPase belonging to the RAS superfamily, which regulates cellular processes like proliferation, differentiation, and survival by cycling between GTP-bound (active) and GDP-bound (inactive) states. While sharing structural homology with classical RAS proteins (HRAS, KRAS, NRAS), RRAS has distinct roles in cell adhesion, migration, and cytoskeletal reorganization, primarily through integrin signaling and pathways like PI3K/Akt and MAPK.
RRAS antibodies are immunological tools designed to detect and study RRAS expression, localization, and function in research or diagnostic contexts. These antibodies are critical for investigating RRAS involvement in diseases, particularly cancer, where aberrant RRAS activity (e.g., mutations, overexpression) may drive tumor progression, metastasis, or angiogenesis. They are also used in neurodevelopmental and cardiovascular studies, as RRAS influences neuronal connectivity and vascular remodeling.
Commercial RRAS antibodies (monoclonal or polyclonal) are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). However, cross-reactivity with other RAS family members remains a challenge, necessitating rigorous validation. Research applications include exploring RRAS as a therapeutic target or biomarker, given its regulatory role in oncogenic pathways. Overall, RRAS antibodies serve as essential reagents for unraveling the protein’s mechanistic contributions to physiology and disease.
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