| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RELB; Transcription factor RelB; I-Rel |
| Entrez GeneID | 5971 |
| WB Predicted band size | Calculated MW: 62 kDa; Observed MW: 62 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Rel B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于RelB抗体的模拟参考文献示例(注：内容为模拟生成，非真实存在的文献)：
1. **《RelB-specific antibodies in the study of dendritic cell maturation》**
作者：Müller, S. et al.
摘要：该研究利用RelB特异性抗体，通过免疫印迹和流式细胞术分析树突细胞成熟过程中RelB蛋白的动态表达，发现RelB在调控抗原呈递中起关键作用。
2. **《Aberrant RelB expression in B-cell lymphoma detected by novel monoclonal antibody》**
作者：Chen, L. & Gupta, R.
摘要：开发了一种新型RelB单克隆抗体，应用于组织样本检测，证实RelB在弥漫大B细胞淋巴瘤中异常高表达，提示其作为潜在生物标志物的价值。
3. **《RelB deficiency alters T-cell immunity: Insights from knockout mouse models》**
作者：Harrison, J.K. et al.
摘要：通过RelB抗体免疫组化分析RelB敲除小鼠的脾脏组织，揭示RelB缺失导致调节性T细胞功能异常，加剧自身免疫反应。
4. **《NF-κB RelB antibody screening in chronic inflammation pathways》**
作者：Park, E. & Wei, H.
摘要：采用RelB抗体抑制实验，证明RelB通过非经典NF-κB通路调控炎症因子IL-23的分泌，为慢性肠炎治疗提供新靶点。
(注：以上文献信息为示例性质，实际引用请以真实数据库查询结果为准。)
Rel B, a member of the NF-κB transcription factor family, plays a distinct role in immune regulation and cellular responses. Structurally, it contains a Rel homology domain (RHD) for DNA binding and dimerization, and a transactivation domain (TAD) for gene activation. Unlike canonical NF-κB proteins like RelA, Rel B primarily operates in the non-canonical pathway, forming complexes with p100 (processed to p52) to regulate gene expression. This pathway is activated by specific receptors, such as CD40. BAFF-R, or lymphotoxin-β receptor, leading to slow but sustained signaling.
Rel B is critical for secondary lymphoid organ development, immune cell differentiation, and adaptive immunity. It promotes dendritic cell maturation, B-cell survival, and T-cell homeostasis. Additionally, it modulates genes involved in inflammation, apoptosis, and immune tolerance. Its activity is tightly regulated through interactions with inhibitory proteins (e.g., p100) and post-translational modifications.
In disease contexts, Rel B exhibits dual roles. It contributes to autoimmune disorders (e.g., rheumatoid arthritis) by sustaining inflammation, while in cancer, it may act as an oncogene or tumor suppressor depending on the context—for example, promoting survival in prostate cancer or suppressing metastasis in certain lymphomas. Rel B-specific antibodies are essential tools in research, enabling detection of its expression, localization, and activation via techniques like Western blotting, immunohistochemistry, and flow cytometry. Studying Rel B provides insights into immune dysregulation and therapeutic targeting for inflammatory diseases and malignancies.
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