| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CENP-34; RASFADIN |
| Entrez GeneID | 9770 |
| WB Predicted band size | Calculated MW: 38 kDa; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human RASSF2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于RASSF2抗体的3篇参考文献示例(注：文献为虚构模拟，仅供格式参考)：
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1. **文献名称**: *RASSF2 suppresses tumor growth through regulation of the Hippo pathway in colorectal cancer*
**作者**: Li Y, et al.
**摘要**: 研究利用RASSF2抗体通过免疫印迹和免疫组化技术，发现RASSF2在结直肠癌中表达下调，其缺失通过激活Hippo通路促进肿瘤增殖，提示其作为抑癌基因的潜在机制。
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2. **文献名称**: *Epigenetic silencing of RASSF2 in breast cancer correlates with poor prognosis*
**作者**: Smith J, et al.
**摘要**: 通过甲基化特异性PCR和RASSF2抗体检测蛋白表达，证实乳腺癌中RASSF2启动子高甲基化导致表达缺失，且与患者生存率显著相关，为预后标志物提供依据。
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3. **文献名称**: *RASSF2 interacts with MDM2 to regulate p53 stability in lung adenocarcinoma*
**作者**: Chen H, et al.
**摘要**: 研究使用RASSF2特异性抗体进行共免疫沉淀实验，揭示RASSF2通过结合MDM2抑制p53降解，在肺癌中发挥抑癌作用，为靶向治疗提供新方向。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“RASSF2 antibody”或“RASSF2 protein function”。
The RASSF2 antibody is a key tool for studying the Ras association domain family member 2 (RASSF2), a tumor suppressor protein implicated in regulating cellular processes such as apoptosis, cell cycle arrest, and microtubule stability. RASSF2 belongs to the RASSF family, which interacts with the Ras oncoprotein and modulates RAS/MAPK signaling pathways. It is frequently epigenetically silenced via promoter hypermethylation in various cancers, including colorectal, lung, and breast cancers, correlating with poor prognosis.
RASSF2 exerts its tumor-suppressive functions by activating the Hippo pathway through interactions with MST1/2 kinases, promoting apoptosis, and inhibiting cell proliferation. It also stabilizes p53 by counteracting MDM2-mediated degradation, enhancing DNA damage responses. Additionally, RASSF2 regulates mitotic progression by interacting with microtubules and mitotic spindle components, ensuring genomic stability.
Antibodies targeting RASSF2 are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and methylation status in cancer research. They help identify RASSF2 downregulation in tumor tissues, providing insights into its role as a biomarker or therapeutic target. Validated antibodies are critical for distinguishing RASSF2 isoforms and confirming functional interactions in signaling cascades. Ongoing studies focus on its potential in cancer diagnostics and restoring RASSF2 expression as a treatment strategy.
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