| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CRLR activity-modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1 |
| Entrez GeneID | 10267 |
| WB Predicted band size | Calculated MW: 17 kDa; Observed MW: 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human RAMP1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于RAMP1抗体的代表性文献(内容基于模拟检索，非真实文献，仅供参考格式)：
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1. **文献名称**: *Targeting RAMP1 with a monoclonal antibody inhibits neurogenic inflammation in migraine models*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种特异性靶向RAMP1的单克隆抗体，并在偏头痛小鼠模型中验证其效果。结果显示，该抗体通过阻断RAMP1与降钙素基因相关肽(CGRP)受体的结合，显著抑制三叉神经节中的CGRP释放和血管扩张，提示其在抗偏头痛药物开发中的潜力。
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2. **文献名称**: *Immunohistochemical localization of RAMP1 in dorsal root ganglia and spinal cord using a novel polyclonal antibody*
**作者**: Lee J, et al.
**摘要**: 作者开发了一种高特异性RAMP1多克隆抗体，并通过免疫组化技术揭示了RAMP1在背根神经节和脊髓背角神经元中的分布。该抗体在Western blot中表现出单一条带，为研究RAMP1在疼痛传导中的功能提供了可靠工具。
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3. **文献名称**: *A RAMP1-neutralizing antibody reduces chronic pancreatitis pain in rodents*
**作者**: Zhang Y, et al.
**摘要**: 研究报道了一种人源化RAMP1中和抗体，可在慢性胰腺炎大鼠模型中减轻疼痛行为和神经炎症反应。机制研究表明，抗体通过抑制CGRP-RAMP1信号通路下调P物质和TNF-α表达，为慢性疼痛治疗提供了新策略。
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注：以上文献为示例，实际引用需以真实数据库(如PubMed)检索结果为准。
The Receptor Activity-Modifying Protein 1 (RAMP1) antibody is a critical tool for studying the RAMP1 protein, a member of the RAMP family that regulates the function and ligand specificity of G protein-coupled receptors (GPCRs). RAMP1 is best known for its role in forming functional calcitonin gene-related peptide (CGRP) receptors by partnering with the calcitonin receptor-like receptor (CLR). This RAMP1-CLR complex is pivotal in mediating CGRP signaling, which is implicated in vasodilation, neurogenic inflammation, and pain pathways, particularly in migraine pathophysiology.
RAMP1 antibodies are widely used to detect RAMP1 expression in tissues or cells, enabling researchers to explore its localization, interaction partners, and regulatory mechanisms. These antibodies are essential in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Their applications extend to both basic research and drug development, especially in the context of therapies targeting CGRP signaling for migraine treatment. Monoclonal and polyclonal RAMP1 antibodies are commercially available, with specificity validated across human, mouse, and rat species. Recent studies also highlight RAMP1's potential roles in cancer, cardiovascular diseases, and metabolic disorders, further driving demand for reliable antibodies to dissect its diverse biological functions. Validation of antibody specificity via knockout controls remains critical to avoid off-target artifacts.
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