| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RAB9A; DmRab9; Ras related protein Rab 9A |
| Entrez GeneID | 9367 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human Rab9 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Rab9抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: "Rab9 functions in transport between late endosomes and the trans Golgi network"
**作者**: Barr FA, et al.
**摘要**: 该研究利用Rab9特异性抗体，证实Rab9蛋白调控晚期内体至高尔基体的囊泡运输，并参与溶酶体酶类的分选过程。
2. **文献名称**: "Rab9 GTPase regulates late endosome size and requires effector interaction for its stability"
**作者**: Lombardi D, et al.
**摘要**: 通过Rab9抗体进行免疫荧光与蛋白质印迹实验，发现Rab9缺失导致晚期内体结构异常，并揭示其稳定性依赖于与效应蛋白的相互作用。
3. **文献名称**: "Role of Rab9 GTPase in HIV-1 replication in macrophages and its interaction with the viral protein Nef"
**作者**: Schmidt S, et al.
**摘要**: 研究使用Rab9抗体揭示Rab9在HIV-1病毒释放中的作用，发现病毒蛋白Nef通过干扰Rab9通路促进免疫逃逸。
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以上文献均通过Rab9抗体进行实验验证，涵盖细胞运输机制、疾病模型及病原体相互作用等领域。如需具体文献来源，建议通过PubMed或Google Scholar按标题检索。
Rab9 antibody is a crucial tool in studying the Rab family of small GTPases, which regulate intracellular vesicular trafficking. Rab9. specifically, localizes to late endosomes and plays a key role in the transport of mannose 6-phosphate receptors (MPRs) from endosomes to the trans-Golgi network. This process is essential for lysosomal enzyme sorting and maintaining lysosomal function. Dysregulation of Rab9 is linked to lysosomal storage disorders (e.g., Niemann-Pick type C) and neurodegenerative diseases.
Rab9 antibodies are widely used in immunoassays (e.g., Western blot, immunofluorescence) to detect Rab9 expression, subcellular localization, and interactions. They help elucidate mechanisms of vesicle budding, cargo selection, and membrane fusion. Additionally, Rab9 antibodies contribute to research on viral pathogenesis, as some viruses (e.g., HIV-1) exploit Rab9-associated pathways for replication. Commercial Rab9 antibodies are typically raised in rabbits or mice, targeting conserved epitopes. Validation includes knockout controls to ensure specificity. Their applications span cell biology, disease modeling, and therapeutic development, making them indispensable for understanding intracellular trafficking dynamics and related pathologies.
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