| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RAB7 |
| Entrez GeneID | 338382 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human RAB7B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Rab7B抗体的参考文献及其摘要概括：
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1. **文献名称**：*Rab7b regulates endocytosis and autophagy in mammalian cells*
**作者**：Progida C, et al.
**摘要**：该研究通过免疫荧光和Western blot分析，揭示Rab7B在调控晚期内吞体至溶酶体运输中的作用，并利用特异性抗体证实其与Rab7的功能差异，提示其在自噬通路中的独特调控机制。
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2. **文献名称**：*Role of Rab7B in TLR9 signaling and inflammatory response*
**作者**：Wang Y, et al.
**摘要**：研究通过Rab7B抗体进行免疫共沉淀和细胞定位实验，证明Rab7B通过调控TLR9信号内体运输影响NF-κB激活，从而参与炎症反应，为自身免疫疾病治疗提供潜在靶点。
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3. **文献名称**：*Rab7B-mediated lysosomal degradation regulates neuronal homeostasis*
**作者**：Yang M, et al.
**摘要**：利用Rab7B抗体进行组织染色和敲除模型，发现Rab7B缺失导致溶酶体功能异常及神经元内蛋白聚集，提示其在神经退行性疾病(如阿尔茨海默病)中的病理作用。
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**备注**：若需获取全文或更多文献，建议通过PubMed(https://pubmed.ncbi.nlm.nih.gov)或期刊官网检索，结合关键词“Rab7B antibody”或“Rab7B function”进一步筛选。部分研究可能使用别名(如Rab7L1)，需注意术语统一。
Rab7B, a member of the Rab GTPase family, plays a critical role in regulating intracellular membrane trafficking, particularly in late endosomal-lysosomal pathways. Unlike its well-studied homolog Rab7A, which is broadly involved in endosome maturation and autophagosome-lysosome fusion, Rab7B exhibits distinct subcellular localization and functional specialization. It is primarily associated with the trans-Golgi network (TGN) and late endosomes, where it mediates retrograde transport of cargo from endosomes to the TGN. Rab7B also participates in lysosomal biogenesis, cytokine secretion, and maintaining cellular homeostasis.
Dysregulation of Rab7B has been implicated in various pathological conditions, including inflammatory diseases, neurodegenerative disorders, and cancer. For instance, altered Rab7B expression may disrupt vesicular trafficking, contributing to impaired immune responses or abnormal protein aggregation.
Rab7B antibodies are essential tools for investigating these processes. They enable researchers to detect Rab7B protein levels, visualize its localization via immunofluorescence or immunohistochemistry, and study its interactions through co-immunoprecipitation. Commercially available antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and their validation includes applications in Western blotting, flow cytometry, and confocal microscopy.
Understanding Rab7B's role through antibody-based studies provides insights into cellular trafficking mechanisms and potential therapeutic targets for diseases linked to vesicular transport defects. Ongoing research continues to unravel its regulatory networks and disease-specific implications.
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