| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PSS2 |
| Entrez GeneID | 81490 |
| WB Predicted band size | Calculated MW: 56 kDa; Observed MW: 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human PTDSS2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于PSS2抗体的3篇参考文献的简要概述(注：PSS2相关研究较少，以下为模拟示例，实际文献需根据具体研究领域核实)：
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1. **文献名称**：*Phosphatidylserine Synthase 2 (PSS2) deficiency alters antibody-mediated immune responses in mice*
**作者**：Sasaki J, et al.
**摘要**：研究通过PSS2抗体检测基因敲除小鼠模型，发现PSS2缺失导致磷脂代谢异常，影响B细胞抗体产生，表明其在适应性免疫中的潜在作用。
2. **文献名称**：*Selective antibody-based detection of phosphatidylserine synthase 2 in cancer cell membranes*
**作者**：Kim DH, et al.
**摘要**：开发了一种高特异性PSS2单克隆抗体，用于免疫荧光和流式细胞术，证实PSS2在多种癌细胞膜上过表达，提示其作为肿瘤标志物的可能性。
3. **文献名称**：*PSS2 antibody validation for lipid droplet proteomics in hepatic steatosis models*
**作者**：Wang Y, et al.
**摘要**：通过Western blot和免疫组化验证PSS2抗体的特异性，并应用于非酒精性脂肪肝模型，发现PSS2与脂滴形成相关蛋白的共定位现象。
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**注意**：以上文献为示例，实际研究中PSS2可能指不同靶标(如磷脂酰丝氨酸合成酶2或磷酸丝氨酸磷酸酶2)。建议结合具体研究领域通过PubMed等数据库检索真实文献。
PSS2 (Phosphatidylserine Synthase 2) is an enzyme encoded by the PTDSS2 gene, playing a critical role in phospholipid metabolism. It catalyzes the synthesis of phosphatidylserine (PS), a key phospholipid component of cell membranes, by exchanging serine for ethanolamine in phosphatidylethanolamine. PS is essential for membrane structure, cellular signaling, and apoptosis, where its externalization triggers phagocytic clearance of dying cells. PSS2 is primarily expressed in the brain, testes, and certain secretory tissues, with its activity localized to the endoplasmic reticulum.
Antibodies targeting PSS2 are vital tools in studying its expression, localization, and function. Research has linked PSS2 dysfunction to human diseases, notably Lenz-Majewski syndrome, a rare genetic disorder characterized by mutations in PTDSS2 that lead to hyperactive enzyme function, resulting in craniofacial abnormalities, skeletal defects, and intellectual disability. Additionally, altered PS metabolism has been implicated in cancer progression, neurodegenerative diseases, and immune regulation, making PSS2 a potential therapeutic target.
PSS2-specific antibodies enable detection of protein levels in disease models, assessment of post-translational modifications, and investigation of interactions with regulatory proteins. Their applications extend to immunohistochemistry, Western blotting, and flow cytometry, aiding in both basic research and clinical diagnostics. Understanding PSS2's role through antibody-based studies could uncover mechanisms underlying lipid-mediated pathologies and guide development of targeted therapies.
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