| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LMP10; MECL1; beta2i |
| Entrez GeneID | 5699 |
| WB Predicted band size | Calculated MW: 29 kDa; Observed MW: 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human PSMB10 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于PSMB10抗体的参考文献示例(注：文献信息为虚拟示例，仅供格式参考)：
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1. **文献名称**: "PSMB10 Expression in Tumor Microenvironment Modulates Antigen Presentation and T Cell Response"
**作者**: Smith A, et al.
**摘要**: 研究通过PSMB10特异性抗体分析多种癌症组织中免疫蛋白酶体亚基的表达，发现PSMB10高表达与增强的肿瘤抗原呈递及CD8+ T细胞浸润相关，提示其在癌症免疫治疗中的潜在价值。
2. **文献名称**: "Dynamic Regulation of Immunoproteasome Subunit PSMB10 during Viral Infection"
**作者**: Chen L, et al.
**摘要**: 利用PSMB10抗体检测病毒感染模型中免疫蛋白酶体的动态变化，证实干扰素-γ通过JAK-STAT通路诱导PSMB10上调，促进病毒抗原加工并增强适应性免疫应答。
3. **文献名称**: "Autoantibodies Targeting PSMB10 in Systemic Lupus Erythematosus"
**作者**: Tanaka K, et al.
**摘要**: 通过ELISA和Western blot验证系统性红斑狼疮(SLE)患者血清中存在抗PSMB10自身抗体，提示PSMB10异常免疫反应可能参与SLE的病理机制。
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如需真实文献，建议在PubMed或Google Scholar中检索关键词“PSMB10 antibody”或“PSMB10 immunoproteasome”，并筛选涉及该抗体应用的基础或临床研究。
The PSMB10 antibody targets the proteasome subunit beta 10 (PSMB10), a key component of the immunoproteasome. PSMB10. also known as LMP2 or β2i, is one of the β-type catalytic subunits that form the 20S core of the proteasome, a large protease complex responsible for degrading intracellular proteins. Unlike constitutive proteasomes, immunoproteasomes incorporate inducible subunits like PSMB10. which are upregulated during inflammation or immune activation, particularly by cytokines such as interferon-gamma (IFN-γ). This specialization enhances the production of antigenic peptides for major histocompatibility complex (MHC) class I presentation, linking PSMB10 to adaptive immune responses.
PSMB10 antibodies are widely used to study immunoproteasome dynamics in diseases like cancer, autoimmune disorders, and neurodegenerative conditions. In cancer, elevated PSMB10 expression may correlate with tumor progression, immune evasion, or chemoresistance. In autoimmune diseases, its dysregulation could contribute to aberrant self-antigen presentation. Researchers employ PSMB10-specific antibodies in techniques such as Western blotting, immunohistochemistry, and flow cytometry to analyze protein expression, localization, and immunoproteasome activity. Recent studies also explore PSMB10 as a potential therapeutic target, with inhibitors under investigation for modulating immune responses or proteostasis in pathological states. Its role in viral infection and cellular stress responses further broadens its research relevance.
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