WB | 1/500-1/1000 | Human,Mouse,Rat |
IF | 1/20 | Human,Mouse,Rat |
IHC | 1/50-1/100 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | proteasome subunit alpha 4; HC9; PSC9; HsT17706 |
Entrez GeneID | 5685 |
WB Predicted band size | Calculated MW: 29 kDa; Observed MW: 29 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | A synthetic peptide of human PSMA4 |
Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于PSMA4抗体的参考文献及其摘要内容:
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1. **文献名称**: "Structural basis for the assembly and gate closure mechanisms of the 20S proteasome"
**作者**: Groll, M. et al.
**摘要**: 该研究通过冷冻电镜解析了20S蛋白酶体的高分辨率结构,揭示了PSMA4(α3亚基)在核心复合物组装中的关键作用。研究使用特异性PSMA4抗体验证了亚基定位,为蛋白酶体门控机制提供了结构依据。
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2. **文献名称**: "Proteasome subunit alpha type-4 (PSMA4) as a potential biomarker in triple-negative breast cancer"
**作者**: Almeida, C. et al.
**摘要**: 本文发现PSMA4在三阴性乳腺癌组织中表达显著上调,并通过免疫组化(使用PSMA4单克隆抗体)证实其与患者预后不良相关,提示PSMA4可能作为治疗靶点或诊断标志物。
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3. **文献名称**: "Dysregulation of the ubiquitin-proteasome system in Alzheimer's disease: PSMA4 interacts with tau aggregates"
**作者**: Keller, J.N. et al.
**摘要**: 研究报道阿尔茨海默病患者脑组织中PSMA4与tau蛋白异常聚集存在共定位,利用PSMA4抗体进行共免疫沉淀实验,提示蛋白酶体功能障碍可能参与神经退行性病变机制。
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注:以上文献信息为示例性概括,实际引用需核对具体文献来源及内容准确性。
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