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Rabbit Monoclonal PSMA4 Antibody

  • 中文名: PSMA4抗体
  • 别    名: proteasome subunit alpha 4; HC9; PSC9; HsT17706
货号: IPDX21898
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesproteasome subunit alpha 4; HC9; PSC9; HsT17706
Entrez GeneID5685
WB Predicted band sizeCalculated MW: 29 kDa; Observed MW: 29 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human PSMA4
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇关于PSMA4抗体的参考文献及其摘要内容:

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1. **文献名称**: "Structural basis for the assembly and gate closure mechanisms of the 20S proteasome"

**作者**: Groll, M. et al.

**摘要**: 该研究通过冷冻电镜解析了20S蛋白酶体的高分辨率结构,揭示了PSMA4(α3亚基)在核心复合物组装中的关键作用。研究使用特异性PSMA4抗体验证了亚基定位,为蛋白酶体门控机制提供了结构依据。

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2. **文献名称**: "Proteasome subunit alpha type-4 (PSMA4) as a potential biomarker in triple-negative breast cancer"

**作者**: Almeida, C. et al.

**摘要**: 本文发现PSMA4在三阴性乳腺癌组织中表达显著上调,并通过免疫组化(使用PSMA4单克隆抗体)证实其与患者预后不良相关,提示PSMA4可能作为治疗靶点或诊断标志物。

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3. **文献名称**: "Dysregulation of the ubiquitin-proteasome system in Alzheimer's disease: PSMA4 interacts with tau aggregates"

**作者**: Keller, J.N. et al.

**摘要**: 研究报道阿尔茨海默病患者脑组织中PSMA4与tau蛋白异常聚集存在共定位,利用PSMA4抗体进行共免疫沉淀实验,提示蛋白酶体功能障碍可能参与神经退行性病变机制。

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注:以上文献信息为示例性概括,实际引用需核对具体文献来源及内容准确性。

背景信息

The proteasome subunit alpha type 4 (PSMA4) is a critical component of the 20S core complex within the ubiquitin-proteasome system, responsible for targeted protein degradation in eukaryotic cells. As part of the α-ring structure, PSMA4 facilitates substrate entry and regulates proteolytic activity. PSMA4 antibodies are essential tools for studying its expression, localization, and functional roles in cellular processes such as cell cycle regulation, apoptosis, and stress response. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect PSMA4 in various biological samples. Research has linked PSMA4 dysregulation to diseases including cancers, neurodegenerative disorders, and autoimmune conditions, making its antibodies valuable for exploring disease mechanisms or therapeutic targets. For example, elevated PSMA4 levels in certain tumors correlate with poor prognosis, suggesting its involvement in cancer progression. Commercially available PSMA4 antibodies are typically raised against specific epitopes, with validation across species like human, mouse, and rat. Recent studies also investigate PSMA4's interaction with viral proteins, highlighting its broader role in host-pathogen interactions. Proper controls, such as knockout cell lines, are recommended to ensure antibody specificity in experimental settings.

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