| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GINS complex subunit 1 |
| Entrez GeneID | 9837 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human PSF1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与PSF1抗体相关的参考文献，供参考：
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1. **文献名称**: *PSF1 (Partner of Sld5-1) is a prognostic marker in colorectal cancer*
**作者**: Tanaka T, et al.
**摘要**: 研究通过免疫组化(使用PSF1抗体)检测结直肠癌组织中PSF1蛋白表达水平，发现高表达PSF1与患者预后不良显著相关，提示其作为潜在生物标志物的价值。
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2. **文献名称**: *DNA replication factor PSF1 as a therapeutic target in cancer*
**作者**: Ishii A, et al.
**摘要**: 利用PSF1特异性抗体进行功能研究，发现抑制PSF1可阻断癌细胞DNA复制并诱导凋亡，为靶向PSF1的抗癌治疗提供实验依据。
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3. **文献名称**: *Characterization of a monoclonal antibody against human PSF1 protein*
**作者**: Yamane M, et al.
**摘要**: 开发并验证了一种高特异性抗人PSF1单克隆抗体，成功应用于Western blot和免疫荧光实验，证实其在多种癌细胞系中的核定位。
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4. **文献名称**: *PSF1 expression predicts chemoresistance in ovarian cancer*
**作者**: Nakamura H, et al.
**摘要**: 通过PSF1抗体检测卵巢癌组织样本，发现PSF1高表达与铂类化疗耐药性显著相关，机制可能与DNA损伤修复通路激活有关。
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以上文献均聚焦于PSF1蛋白的功能及其抗体在基础研究与临床中的应用，涵盖预后评估、治疗靶点及抗体开发方向。如需全文可通过PubMed或期刊官网查询具体信息。
The PSF1 (Partner of SLD5) antibody is a valuable tool for studying the role of the PSF1 protein in DNA replication and repair processes. PSF1. also known as hPSF1 or SLD5. is a critical component of the GINS complex (Go-Ichi-Ni-San), which is essential for the initiation and progression of DNA replication in eukaryotic cells. This complex stabilizes replication forks and ensures proper DNA synthesis during the S phase of the cell cycle. PSF1's interaction with other GINS members (PSF2. PSF3. and SLD5) facilitates the recruitment of key enzymes like DNA polymerases to replication origins.
Researchers use PSF1 antibodies primarily in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate its expression, localization, and regulatory mechanisms. Studies have linked PSF1 overexpression to aggressive cancer phenotypes, including uncontrolled proliferation and poor prognosis in malignancies like colorectal, breast, and lung cancers. Consequently, PSF1 is explored as a potential biomarker for tumor progression and a therapeutic target.
Most commercially available PSF1 antibodies are raised against synthetic peptide antigens, often in rabbit or mouse hosts, and validated for specificity across human and model organism samples. Its role in maintaining genomic stability continues to drive research in oncology, developmental biology, and diseases associated with replication stress.
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