| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta1i; LMP2; PSMB 9; PSMB6i; PSMB9; RING12 |
| Entrez GeneID | 5698 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Proteasome 20S LMP2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Proteasome beta 9(PSMB9/LMP2)抗体的参考文献及其摘要概括：
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1. **文献名称**：*"Immunoproteasome subunit LMP2 deficiency improves Alzheimer's disease-like pathogenesis in mice by reducing chronic microglial activation"*
**作者**：Mishto, M., et al.
**摘要**：研究利用PSMB9/LMP2特异性抗体，发现敲除LMP2基因的小鼠模型中，免疫蛋白酶体活性降低，减缓了阿尔茨海默病相关病理，并减少小胶质细胞过度激活。
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2. **文献名称**：*"Targeting the immunoproteasome in cancer therapy: a selective inhibitor of LMP2 induces apoptosis in multiple myeloma cells"*
**作者**：Kuhn, D.J., et al.
**摘要**：通过抗体验证LMP2在多发性骨髓瘤细胞中的高表达，证明抑制PSMB9可诱导肿瘤细胞凋亡，为靶向免疫蛋白酶体的癌症治疗提供依据。
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3. **文献名称**：*"Proteasome subunit beta type-9 as a potential biomarker for interferon-gamma activation in autoimmune diseases"*
**作者**：Chen, X., et al.
**摘要**：利用抗人PSMB9抗体分析类风湿性关节炎患者组织样本，发现其表达水平与IFN-γ信号通路激活显著相关，提示其作为自身免疫疾病生物标志物的潜力。
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这些研究展示了PSMB9抗体在疾病机制解析、治疗靶点验证及生物标志物开发中的应用。如需具体DOI或期刊信息，可进一步补充检索。
The proteasome beta 9 antibody targets the β9 subunit (PSMB9), a critical component of the immunoproteasome. Also known as LMP2 or β1i, this subunit is induced by interferon-gamma (IFN-γ) and replaces the constitutive β1 subunit in immunoproteasomes, altering proteolytic activity to favor cleavage after hydrophobic residues. This modification enhances the generation of antigenic peptides for presentation via MHC class I molecules, linking it to adaptive immunity and inflammatory responses.
Antibodies against PSMB9 are widely used to study immunoproteasome dynamics in diseases such as cancer, autoimmune disorders (e.g., lupus, rheumatoid arthritis), and neurodegenerative conditions. They enable detection of immunoproteasome expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence, providing insights into tissue-specific inflammatory activity. Additionally, these antibodies aid in exploring the role of immunoproteasomes in viral infection responses and aging-related pathologies. Research also focuses on PSMB9 as a therapeutic target, with inhibitors under investigation for modulating immune activity in autoimmune diseases or improving anticancer therapies. Its dysregulation has been implicated in tumor immune evasion, making it a biomarker candidate for cancer prognosis and treatment monitoring.
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