| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HC3; PMSA2; Proteasome component C3; PSC2; PSC3; psmA2 |
| Entrez GeneID | 5683 |
| WB Predicted band size | Calculated MW: 26 kDa; Observed MW: 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Proteasome 20S alpha 2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 **Proteasome alpha 2(PSMA2)抗体**的3篇参考文献示例(内容为虚构，供参考)：
1. **文献名称**：*Proteasome subunit alpha type-2 as a novel biomarker in hepatocellular carcinoma*
**作者**：Chen L, et al.
**摘要**：研究通过免疫组化(IHC)和Western blot分析，发现PSMA2在肝癌组织中高表达，其抗体特异性可用于癌症预后评估及靶向治疗研究。
2. **文献名称**：*Characterization of a monoclonal antibody targeting proteasome α2 subunit for neurodegenerative disease models*
**作者**：Smith J, et al.
**摘要**：开发了一种高特异性抗PSMA2单克隆抗体，验证了其在阿尔茨海默病小鼠模型中蛋白酶体功能异常的检测应用。
3. **文献名称**：*Proteasome α2 subunit modulates oxidative stress response via antibody-based inhibition assay*
**作者**：Wang Y, et al.
**摘要**：利用PSMA2抗体阻断蛋白酶体活性，揭示该亚基在细胞氧化应激调控中的关键作用，为相关药物开发提供依据。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed或Google Scholar。)
The proteasome alpha 2 antibody is a research tool targeting the α2 subunit of the 20S core particle within the ubiquitin-proteasome system (UPS). The 20S proteasome, a barrel-shaped complex, comprises four stacked rings: two outer α-rings (containing seven α subunits, including α2) and two inner β-rings. The α subunits, including α2 (encoded by *PSMA2*), primarily regulate substrate entry and stabilize the proteasome structure, while β subunits mediate proteolytic activity. As a key component of cellular protein degradation, the proteasome is critical for maintaining protein homeostasis, regulating processes like cell cycle progression, stress responses, and immune antigen presentation.
Antibodies against proteasome alpha 2 are widely used to study proteasome composition, localization, and expression in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. These antibodies (often monoclonal or polyclonal, derived from rabbits or mice) enable techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help investigate proteasome dysfunction in pathologies—e.g., reduced proteasome activity in aging neurons or overexpression in certain cancers. Specificity validation is essential, as cross-reactivity with other α subunits may occur. Commercial antibodies are typically validated for species reactivity (human, mouse, rat) and application-specific performance. Research using alpha 2 antibodies contributes to understanding UPS-related disease mechanisms and therapeutic targeting of proteasome inhibitors.
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