| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS |
| Entrez GeneID | 5730 |
| WB Predicted band size | Calculated MW: 21 kDa; Observed MW: 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Prostaglandin D Synthase |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Prostaglandin D Synthase(PTGDS)抗体的3篇参考文献，按研究内容和应用方向概括：
1. **文献名称**: "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma"
**作者**: Fujimoto et al.
**摘要**: 该研究利用特异性抗体检测脂钙蛋白型PTGDS在人类睾丸、附睾及精液中的高表达，证实其作为主要前列腺素D2合成酶在生殖系统中的潜在功能，并探讨其在精子活力调控中的作用。
2. **文献名称**: "Prostaglandin D synthase as a biomarker for neurological diseases: Development of a sandwich ELISA and immunohistochemical analysis"
**作者**: Eguchi et al.
**摘要**: 研究团队开发了针对PTGDS的高灵敏度单克隆抗体，建立了双抗体夹心ELISA方法，用于定量脑脊液中的PTGDS水平，并验证其在多发性硬化症和阿尔茨海默病中的生物标志物潜力。
3. **文献名称**: "Purification and characterization of rat brain prostaglandin D synthetase and its immunohistochemical localization"
**作者**: Mizuguchi et al.
**摘要**: 通过纯化大鼠脑PTGDS蛋白并制备兔多克隆抗体，研究发现该酶广泛分布于脑胶质细胞和脑膜中，提示其在神经炎症和睡眠-觉醒周期中的关键作用。
4. **文献名称**: "The role of prostaglandin D synthase in the pathogenesis of Parkinson's disease"
**作者**: Ikeda et al.
**摘要**: 使用PTGDS特异性抗体进行免疫组化分析，发现帕金森病患者黑质区域PTGDS表达显著上调，提示其可能通过调节神经炎症或氧化应激参与疾病进展。
这些文献涵盖了PTGDS抗体在生殖系统、神经疾病诊断及病理机制研究中的应用，包括定量检测、组织定位及功能探索。
Prostaglandin D synthase (PGDS) antibody is a research tool used to detect and study the enzyme responsible for synthesizing prostaglandin D₂ (PGD₂), a lipid mediator involved in various physiological and pathological processes. PGDS exists in two isoforms: lipocalin-type PGDS (L-PGDS or PTGDS), primarily expressed in the brain, cerebrospinal fluid, and male genital organs, and hematopoietic PGDS (H-PGDS or PTGDS2), found in immune cells like mast cells and macrophages.
PGD₂ regulates functions such as sleep induction, inflammation, allergic responses, and nociception. Antibodies targeting PGDS are essential for investigating its expression, localization, and role in diseases. For example, L-PGDS is linked to neurological disorders (e.g., Alzheimer’s disease) and metabolic syndromes, while H-PGDS is implicated in allergic asthma and tumor progression. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify PGDS levels in tissues or fluids, aiding in biomarker discovery or therapeutic target validation.
Commercial PGDS antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides. Specificity is validated through knockout controls or blocking assays. Researchers must select antibodies validated for their intended applications, as cross-reactivity between isoforms or species can occur. Overall, PGDS antibodies remain critical for unraveling the enzyme’s biological significance and its potential as a diagnostic or therapeutic target.
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