| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prealbumin; TBPA; Amyloidosis I; Transthyretin |
| Entrez GeneID | 7276 |
| WB Predicted band size | Calculated MW: 16 kDa; Observed MW: 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Prealbumin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Prealbumin抗体的3篇参考文献及其摘要信息：
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1. **文献名称**：*Production and characterization of monoclonal antibodies to human prealbumin*
**作者**：Skinner, M., et al.
**摘要**：该研究描述了针对人前白蛋白(Transthyretin)的单克隆抗体的制备与特性分析，揭示了其在免疫检测中的高特异性和对淀粉样变性相关突变的识别能力。
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2. **文献名称**：*Immunoassays for the detection of transthyretin in cerebrospinal fluid*
**作者**：Gustafsson, S., et al.
**摘要**：研究开发了一种基于Prealbumin抗体的免疫检测方法，用于定量脑脊液中的Transthyretin水平，探讨其在阿尔茨海默病中与β-淀粉样蛋白沉积的潜在关联。
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3. **文献名称**：*Prealbumin variants in familial amyloidotic polyneuropathy: antigenic and structural differences*
**作者**：Saraiva, M.J.M., et al.
**摘要**：通过Prealbumin抗体分析遗传性淀粉样变性患者的突变型Transthyretin，揭示了不同突变体在抗原表位和蛋白构象上的差异，为疾病机制研究提供依据。
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注：以上文献为示例性内容，实际引用需核对具体论文数据库(如PubMed)的完整信息。
**Background of Prealbumin Antibodies**
Prealbumin, also known as transthyretin (TTR), is a 55 kDa tetrameric protein synthesized primarily in the liver and choroid plexus. It functions as a carrier for thyroid hormones (T3/T4) and retinol-binding protein (RBP), playing roles in nutrient transport and amyloid fibril formation. Prealbumin’s serum levels are clinically monitored as a biomarker for malnutrition, inflammation, and certain diseases, including hereditary transthyretin amyloidosis (hATTR) and Alzheimer’s disease, where misfolded TTR aggregates contribute to pathology.
Antibodies targeting prealbumin are essential tools in research and diagnostics. Polyclonal and monoclonal antibodies are generated using purified human or recombinant TTR as immunogens. These antibodies enable the detection and quantification of prealbumin via techniques like ELISA, Western blotting, and immunohistochemistry. In research, they help study TTR’s structural dynamics, tissue distribution, and aggregation mechanisms. Clinically, prealbumin-specific antibodies aid in diagnosing amyloidosis through biopsy staining or detecting abnormal TTR variants in genetic screenings.
Recent advancements focus on developing therapeutic antibodies to stabilize TTR tetramers, inhibit amyloidogenesis, or promote clearance of aggregated forms. Challenges include ensuring antibody specificity to avoid cross-reactivity with homologous proteins and optimizing affinity for clinical sensitivity. Overall, prealbumin antibodies remain pivotal in understanding TTR-related pathologies and advancing targeted therapies.
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