首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal PPP2R5D Antibody

  • 中文名： PPP2R5D抗体
  • 别    名： B56D; MRD35; B56delta
货号: IPDX21873
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesB56D; MRD35; B56delta
Entrez GeneID5528
WB Predicted band sizeCalculated MW: 70 kDa; Observed MW: 70,66 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant protein of human PPP2R5D
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是关于PPP2R5D抗体的3篇参考文献示例(注：部分内容可能为虚构或示例性描述，仅供参考)：

---

1. **文献名称**: *PPP2R5D regulates neuronal development through AKT/mTOR signaling*

**作者**: Smith J, et al.

**摘要**: 本研究揭示了PPP2R5D在神经元分化中的作用，通过Western blot和免疫荧光技术使用PPP2R5D特异性抗体，发现其通过调控AKT/mTOR通路影响突触形成。抗体验证显示PPP2R5D在脑组织中高表达。

2. **文献名称**: *PPP2R5D as a prognostic biomarker in colorectal cancer*

**作者**: Lee H, et al.

**摘要**: 研究利用PPP2R5D抗体进行免疫组化分析，发现其在结直肠癌中表达下调，并与患者生存率正相关。机制研究表明PPP2R5D通过抑制Wnt/β-catenin通路发挥抑癌作用。

3. **文献名称**: *Structural and functional characterization of the PP2A-B56δ holoenzyme*

**作者**: Wang Y, et al.

**摘要**: 通过冷冻电镜和免疫共沉淀(使用PPP2R5D抗体)，解析了PP2A-B56δ复合物的结构，揭示了PPP2R5D在调节底物选择性和细胞周期调控中的分子机制。

---

**注意**：以上文献及摘要内容为示例性质，实际文献需通过PubMed、Google Scholar等平台检索确认。若需具体文献，建议使用关键词“PPP2R5D antibody”或“PPP2R5D function”进一步查询。

背景信息

The PPP2R5D antibody is a crucial tool in studying the regulatory subunit B56δ of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in diverse cellular processes. PPP2R5D (Protein Phosphatase 2 Regulatory Subunit B56 Delta) encodes one of five B56 family members (B56α–ε) that dictate PP2A’s substrate specificity, localization, and activity. PP2A complexes, comprising a structural (A), catalytic (C), and regulatory (B) subunit, regulate signaling pathways critical to cell cycle progression, apoptosis, and stress responses. The B56δ subunit, encoded by PPP2R5D, is implicated in modulating Wnt/β-catenin, PI3K/AKT, and DNA damage response pathways. Dysregulation of PPP2R5D is linked to cancers, neurodegenerative diseases, and developmental disorders. Antibodies targeting PPP2R5D enable researchers to investigate its expression, post-translational modifications, and interactions within PP2A holoenzymes via techniques like Western blotting, immunoprecipitation, and immunofluorescence. These studies are vital for understanding PP2A’s tumor-suppressive roles and its context-dependent oncogenic functions. Additionally, PPP2R5D mutations are associated with intellectual disability and autism spectrum disorders, making such antibodies valuable in neurodevelopmental research. Commercial PPP2R5D antibodies are typically validated for specificity across human and model organisms, aiding translational studies exploring PPP2R5D as a therapeutic target or biomarker in disease.

客户数据及评论

折叠内容

大包装询价

×