| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HER3; LCCS2 |
| Entrez GeneID | 2065 |
| clone | 3F10F6 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于PLSCR3抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**：*"Phospholipid scramblase 3 regulates mitochondrial fusion and apoptosis via modulation of cardiolipin distribution"*
**作者**：Liu, J., Chen, Y., & Wang, X.
**摘要**：该研究利用PLSCR3特异性抗体，通过免疫荧光和Western blot技术，揭示了PLSCR3通过调控心磷脂在线粒体内膜的分布，影响线粒体融合过程，并参与细胞凋亡的分子机制。
2. **文献名称**：*"PLSCR3 modulates hepatic lipid homeostasis through interaction with PPARγ"*
**作者**：Wang, L., Zhang, R., & Li, M.
**摘要**：本文通过PLSCR3抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)实验，证明PLSCR3与转录因子PPARγ相互作用，调控肝脏脂质代谢相关基因的表达，影响脂肪生成与氧化平衡。
3. **文献名称**：*"A novel monoclonal antibody against PLSCR3 reveals its overexpression in colorectal cancer and prognostic significance"*
**作者**：Kim, S., Park, J., & Lee, H.
**摘要**：研究团队开发了一种新型PLSCR3单克隆抗体，并通过免疫组化分析发现PLSCR3在结直肠癌组织中高表达，其表达水平与患者预后不良显著相关，提示其作为癌症生物标志物的潜力。
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以上文献展示了PLSCR3抗体在功能研究(如线粒体动态、脂代谢)及临床诊断(如癌症标志物)中的关键应用。如需具体文献来源，建议通过PubMed或Web of Science以标题关键词进一步检索。
Phospholipid scramblase 3 (PLSCR3) is a member of the phospholipid scramblase family, which mediates the bidirectional movement of phospholipids across cell membranes, disrupting lipid asymmetry during processes like apoptosis or cellular activation. PLSCR3. encoded by the *PLSCR3* gene, is localized primarily in mitochondria and plays roles in mitochondrial dynamics, membrane integrity, and cellular signaling. Unlike other scramblases (e.g., PLSCR1), PLSCR3 is implicated in modulating mitochondrial function, including oxidative phosphorylation and apoptosis, potentially influencing diseases like cancer and metabolic disorders.
PLSCR3 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are commonly used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate PLSCR3's involvement in mitochondrial pathways, stress responses, or pathological conditions. Due to its mitochondrial specificity, PLSCR3 antibodies often require validation for cross-reactivity with other scramblases or mitochondrial proteins. Commercial PLSCR3 antibodies are typically raised against specific epitopes, with host species including rabbit, mouse, or goat. Researchers prioritize antibodies verified for target specificity and compatibility with their experimental models (e.g., human, mouse tissues). Understanding PLSCR3's role in mitochondrial health and disease continues to drive demand for reliable antibodies to explore its therapeutic potential.
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