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Rabbit Monoclonal PKCbeta1 Antibody

  • 中文名： PKC beta 1抗体
  • 别    名： PRKCB; PKCB; PRKCB1; Protein kinase C beta type; PKC-B; PKC-beta
货号: IPDX21852
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPRKCB; PKCB; PRKCB1; Protein kinase C beta type; PKC-B; PKC-beta
Entrez GeneID5579
WB Predicted band sizeCalculated MW: 77 kDa; Observed MW: 77 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human PKC beta 2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于PKCβ1抗体的3篇参考文献示例(注：文献信息为虚构示例，仅用于演示格式)：

1. **文献名称**：*Role of PKCβ1 in Diabetic Retinopathy: Insights from Immunohistochemical Analysis*

**作者**：Smith A, et al.

**摘要**：通过PKCβ1抗体进行视网膜组织免疫组化分析，揭示其在糖尿病模型中的异常激活与血管通透性增加相关，提示PKCβ1作为治疗靶点。

2. **文献名称**：*PKCβ1 Antibody-Based Detection of Isoform-Specific Signaling in Colorectal Cancer*

**作者**：Lee H, et al.

**摘要**：利用特异性PKCβ1抗体进行Western blot和流式细胞术，发现PKCβ1在结肠癌中高表达，并与化疗耐药性相关。

3. **文献名称**：*PKCβ1 Inhibition Attenuates Neuronal Apoptosis in Ischemic Stroke Models*

**作者**：Wang Y, et al.

**摘要**：通过PKCβ1抗体阻断实验结合基因沉默技术，证实PKCβ1在脑缺血损伤中促进神经元凋亡，其抑制剂具有神经保护潜力。

(注：实际文献需通过PubMed/Google Scholar等平台检索关键词“PKC beta 1 antibody”或“PRKCB1”获取。)

背景信息

The protein kinase C beta 1 (PKCβ1) antibody is a research tool targeting the PKCβ1 isoform, a member of the protein kinase C (PKC) family of serine/threonine kinases. PKCβ1 is involved in diverse cellular processes, including proliferation, apoptosis, and differentiation, by modulating signaling pathways such as PI3K/Akt and MAPK. It is activated by diacylglycerol (DAG) and calcium, playing critical roles in immune responses, neuronal function, and vascular regulation. Dysregulation of PKCβ1 has been linked to cancer, diabetes (e.g., vascular complications), and inflammatory diseases. The antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to detect PKCβ1 expression and localization in tissues or cell lines. Commercially available PKCβ1 antibodies are often raised against specific epitopes, such as the C-terminal region, and validated for specificity using knockout controls. Researchers utilize these antibodies to explore PKCβ1's role in disease mechanisms or therapeutic targeting, particularly in contexts like B-cell signaling and chemoresistance. Variants like PKCβI (full-length) and PKCβII (alternatively spliced) may require isoform-specific validation to avoid cross-reactivity.

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