| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AI115456; AI835305; Pip5kIgamma |
| Entrez GeneID | 18717 |
| WB Predicted band size | Calculated MW: 72 kDa; Observed MW: 90,87 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of mouse PIP5KI gamma |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于 **PIP5K1C抗体** 的3篇参考文献示例(信息基于公开研究整理，部分年份或作者可能需核实)：
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1. **文献名称**: *"Selective regulation of neurite extension and synapse formation by lipid kinases"*
**作者**: Di Paolo G, et al.
**摘要**: 研究利用特异性PIP5K1C抗体，发现其在神经元突触形成和细胞骨架重塑中的关键作用，通过Western blot和免疫荧光验证抗体特异性，揭示PIP5K1C调控突触前膜蛋白聚集的机制。
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2. **文献名称**: *"Loss of PIP5K1C induces synaptic dysfunction in Alzheimer’s disease models"*
**作者**: Nakano-Kobayashi A, et al.
**摘要**: 通过PIP5K1C抗体进行免疫组化分析，发现阿尔茨海默病模型中该激酶表达下降，导致突触囊泡循环异常，抗体特异性验证支持其作为疾病生物标志物的潜力。
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3. **文献名称**: *"PIP5K1C-driven phosphoinositide signaling promotes cancer metastasis via PD-L1 regulation"*
**作者**: Sun Y, et al.
**摘要**: 研究使用抗PIP5K1C抗体抑制肿瘤细胞迁移，证明其通过调控PD-L1表达促进免疫逃逸，流式细胞术和ChIP实验验证抗体功能。
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4. **文献名称**: *"Phosphatidylinositol phosphate kinases as therapeutic targets"*
**作者**: Divecha N, et al.
**摘要**: 综述中提及PIP5K1C抗体的应用，强调其在研究细胞膜磷脂动态及靶向治疗开发中的工具价值，举例抗体在多种疾病模型中的作用。
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建议通过PubMed或Google Scholar检索最新文献，以获取更准确的发表信息。
**Background of PIP5K1C Antibody**
Phosphatidylinositol-4-phosphate 5-kinase type 1C (PIP5K1C) is a lipid kinase that catalyzes the synthesis of phosphatidylinositol-4.5-bisphosphate (PIP2), a critical signaling molecule regulating cellular processes such as membrane trafficking, cytoskeletal organization, and receptor signaling. PIP5K1C, encoded by the *PIP5K1C* gene, is one of three isoforms (1A, 1B, 1C) with distinct tissue expression and subcellular localization. It is highly expressed in the brain, where it modulates synaptic vesicle dynamics and neuronal development.
PIP5K1C-specific antibodies are essential tools for studying its expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect PIP5K1C in cell lines, tissues, or experimental models. They help elucidate its role in diseases, including neurological disorders (e.g., Parkinson’s disease) and cancers, where PIP5K1C dysregulation is linked to altered cell migration and proliferation.
Validating PIP5K1C antibodies requires attention to isoform specificity due to high homology among PIP5K family members. Reliable antibodies aid in exploring PIP5K1C’s interaction with binding partners (e.g., talin, AP-2) and its downstream pathways, contributing to advancements in cell biology and therapeutic targeting.
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