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Rabbit Monoclonal PIN4 Antibody

  • 中文名： PIN4抗体
  • 别    名： EPVH; PAR14; PAR17
货号: IPDX21850
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Rat,Hamster
IF 1/20 Human,Rat,Hamster
IHC 咨询技术 Human,Rat,Hamster
ICC 技术咨询 Human,Rat,Hamster
FCM 咨询技术 Human,Rat,Hamster
Elisa 咨询技术 Human,Rat,Hamster

产品详情

AliasesEPVH; PAR14; PAR17
Entrez GeneID5303
WB Predicted band sizeCalculated MW: 14 kDa; Observed MW: 14 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat,Hamster
ImmunogenA synthetic peptide of human PIN4
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于PIN4抗体的示例参考文献(内容为模拟生成，仅供参考)：

1. **《PIN4 Antibody Characterization in Plant Development》**

- 作者：Smith J, et al.

- 摘要：研究拟南芥中PIN4蛋白的极性定位，通过特异性抗体揭示其在根尖干细胞微环境中的动态表达，证实PIN4对植物激素运输的关键作用。

2. **《A Novel PIN4 Antibody for Detecting Phosphorylated Tau in Alzheimer’s Disease》**

- 作者：Lee S, et al.

- 摘要：开发了一种高特异性PIN4抗体，用于识别磷酸化tau蛋白的异构体，揭示其在阿尔茨海默病患者脑组织中的异常聚集，为病理诊断提供新工具。

3. **《PPIase PIN4 Inhibition and Cancer Therapy: Insights from Antibody-Based Targeting》**

- 作者：Zhang R, et al.

- 摘要：利用单克隆PIN4抗体靶向抑制PPI酶活性，证明其在抑制肿瘤细胞增殖和增强化疗敏感性中的潜力，为癌症治疗提供新策略。

4. **《Dynamic Localization of PIN4 in Human Cell Cycle Progression》**

- 作者：Brown K, et al.

- 摘要：通过免疫荧光结合PIN4抗体，追踪蛋白在有丝分裂中的时空分布，阐明其与NIMA激酶互作调控细胞周期进程的机制。

(注：以上文献为示例，实际引用请根据具体研究领域核实真实文献。)

背景信息

The PIN4 antibody is a valuable tool in biomedical research, primarily targeting the phosphorylated form of the peptidyl-prolyl cis-trans isomerase Pin1. Pin1. encoded by the PIN1 gene, regulates protein conformation by catalyzing proline-directed phosphorylation-dependent cis-trans isomerization, impacting cell cycle progression, transcription, and apoptosis. Its dysregulation is linked to cancers and neurodegenerative diseases like Alzheimer's. The PIN4 antibody specifically recognizes phosphorylated serine/threonine-proline motifs in target proteins, a post-translational modification critical for Pin1's interaction with substrates such as tau, β-catenin, and cyclin D1. Researchers use this antibody to study Pin1's role in disease mechanisms, particularly in cancer (e.g., breast, prostate) where Pin1 overexpression correlates with poor prognosis, and in Alzheimer's research focusing on hyperphosphorylated tau aggregation. It is commonly employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to visualize phosphorylation-dependent protein dynamics. The antibody's phospho-specificity helps distinguish active signaling states in pathological samples, making it crucial for understanding disease biomarkers and therapeutic targets. Commercial variants are available from multiple suppliers, often validated for specificity through knockout controls.

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