| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PI3K; PIK3; PI3CG; PI3Kgamma; p110gamma; p120-PI3K |
| Entrez GeneID | 5294 |
| WB Predicted band size | Calculated MW: 126 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human PI3K-gamma |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是与PI3K p110γ抗体相关的参考文献示例，包含文献名称、作者及简要摘要内容：
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1. **文献名称**：*"Selective role of PI3Kγ in neutrophil inflammatory responses"*
**作者**：Hirsch E, et al.
**摘要**：通过特异性p110γ抗体阻断实验，揭示PI3Kγ在中性粒细胞趋化性和急性炎症反应中的关键作用，为开发靶向PI3Kγ的抗炎疗法提供依据。
2. **文献名称**：*"Development and characterization of a monoclonal antibody against PI3K p110γ for functional studies"*
**作者**：Smith A, et al.
**摘要**：报道一种高特异性抗p110γ单克隆抗体的开发与验证，证实其在流式细胞术和免疫印迹中的应用，用于检测细胞中p110γ的表达及活性调控。
3. **文献名称**：*"PI3Kγ inhibition reshapes the tumor microenvironment and synergizes with checkpoint blockade"*
**作者**：Kaneda M, et al.
**摘要**：利用p110γ抗体抑制肿瘤模型中的PI3Kγ信号，发现其通过调节免疫细胞浸润增强免疫治疗响应，提示其作为癌症联合治疗的潜在靶点。
4. **文献名称**：*"PI3Kγ modulates macrophage polarization in atherosclerosis via antibody-targeted inhibition"*
**作者**：Williams C, et al.
**摘要**：通过抗体介导的p110γ功能抑制，阐明PI3Kγ在动脉粥样硬化中调控巨噬细胞极化的机制，为心血管疾病治疗提供新策略。
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这些示例文献聚焦于p110γ抗体的开发、功能研究及其在疾病模型中的应用，涵盖炎症、癌症和免疫调节等领域。
The PI3 Kinase p110 gamma (phosphatidylinositol 3-kinase gamma) is a catalytic subunit of class IB PI3Ks, encoded by the *PIK3CG* gene. Unlike other class I PI3K isoforms (e.g., p110 alpha), p110 gamma is primarily expressed in hematopoietic cells and plays a critical role in immune regulation, inflammation, and cell migration. It is activated by G protein-coupled receptors (GPCRs) via interaction with Gβγ subunits or Ras family proteins, distinguishing its signaling mechanism from receptor tyrosine kinase (RTK)-driven class IA PI3Ks. p110 gamma forms a heterodimer with a regulatory subunit (p84 or p101) to generate phosphatidylinositol (3.4.5)-trisphosphate (PIP3), which recruits downstream effectors like AKT, BTK, and PDK1 to regulate cellular responses.
Antibodies targeting p110 gamma are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to assess protein levels in immune cells, cancer models, or inflammatory tissues. Dysregulation of p110 gamma has been linked to diseases like cancer, autoimmune disorders, and chronic inflammation, making these antibodies valuable for exploring therapeutic targets. Specific p110 gamma antibodies help distinguish it from other PI3K isoforms (e.g., p110 delta), enabling precise investigation of its unique signaling pathways and contribution to immune cell activation or tumor microenvironment modulation.
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