| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p40; RAB9p40; RABEPK; RGD1310612; RP11 65N13.1; RP23-446N16.2 |
| Entrez GeneID | 10244 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human p40 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3篇关于p40抗体的参考文献及其摘要概括：
---
1. **文献名称**: *p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma*
**作者**: Bishop JA, et al.
**摘要**: 该研究比较了p40和p63抗体在肺鳞状细胞癌诊断中的特异性，发现p40作为p63的亚型抗体，对鳞状分化具有更高特异性，可减少与其他肿瘤类型的交叉反应。
---
2. **文献名称**: *Utility of p40 in the differential diagnosis of small round blue cell tumors*
**作者**: Rekhtman N, et al.
**摘要**: 探讨p40抗体在鉴别小圆蓝细胞肿瘤中的应用，指出其在诊断鳞状细胞癌和基底样癌中的关键作用，尤其在胸腺瘤和胸腺癌中的表达差异。
---
3. **文献名称**: *p40: A p63 isoform useful for lung carcinoma diagnosis*
**作者**: Pelosi G, et al.
**摘要**: 研究验证了p40抗体在非小细胞肺癌(NSCLC)亚型分型中的价值，强调其作为鳞癌特异性标志物，在腺癌与鳞癌鉴别中的高敏感性和特异性。
---
如果需要具体文献来源或补充更多研究，可进一步提供数据库检索信息。
The p40 antibody is a diagnostic and research tool targeting the p40 subunit, a shared component of interleukin-12 (IL-12) and interleukin-23 (IL-23), two cytokines critical in adaptive and innate immunity. IL-12. composed of p35 and p40 subunits, drives Th1 cell differentiation and interferon-gamma production, while IL-23 (p19/p40) promotes Th17 cell-mediated inflammatory responses. The p40 subunit’s dual role in these cytokines makes it a focal point in studying immune dysregulation.
In diagnostics, p40 antibodies are widely used in immunohistochemistry (IHC) to identify squamous cell carcinomas, as p40 (ΔNp63) is a nuclear marker expressed in squamous epithelial cells. It helps distinguish squamous from non-squamous neoplasms, particularly in lung and head/neck cancers.
Research applications include investigating IL-12/IL-23 pathways in autoimmune diseases (e.g., psoriasis, inflammatory bowel disease) and cancer immunotherapy. Therapeutic agents like ustekinumab, a monoclonal antibody targeting p40. block both IL-12 and IL-23 signaling, demonstrating its clinical relevance.
The p40 antibody thus bridges basic research and clinical practice, aiding in understanding immune mechanisms, disease classification, and targeted therapy development.
×
