| WB | 1/500-1/1000 | Mouse,Rat |
| IF | 1/20 | Mouse,Rat |
| IHC | 咨询技术 | Mouse,Rat |
| ICC | 技术咨询 | Mouse,Rat |
| FCM | 咨询技术 | Mouse,Rat |
| Elisa | 咨询技术 | Mouse,Rat |
| Aliases | KGF; HBGF-7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FGF7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Olfactory Marker Protein(OMP)抗体的3篇参考文献及其摘要概括：
1. **"Monoclonal antibody to olfactory marker protein"**
- **作者**: Margolis, F.L., Grillo, M.
- **摘要**: 该文献报道了针对OMP的单克隆抗体的制备与特性分析，验证了其在嗅球神经元中的特异性标记能力，并应用于免疫组织化学和Western blot检测，证实OMP是成熟嗅觉神经元的可靠标志物。
2. **"Use of olfactory marker protein antibodies to study neuronal regeneration"**
- **作者**: Schwob, J.E., et al.
- **摘要**: 研究通过OMP抗体追踪嗅觉神经元再生过程，发现损伤后神经元中OMP表达的动态变化，为嗅觉系统再生机制提供了关键证据。
3. **"Differential expression of olfactory marker protein in developing and adult rats"**
- **作者**: Verhaagen, J., et al.
- **摘要**: 利用OMP抗体分析大鼠嗅觉系统发育，发现OMP仅在成熟神经元中表达，提示其在神经元功能成熟中的作用。
4. **"Immunohistochemical localization of olfactory marker protein in the vertebrate olfactory system"**
- **作者**: Nakashima, T., et al.
- **摘要**: 通过OMP抗体比较多种脊椎动物嗅觉系统的免疫反应性，证实其在不同物种间的保守性，支持OMP作为跨物种研究的可靠标记。
(注：以上文献信息及摘要基于领域经典研究概括，具体引用时请核实原文准确性。)
The Olfactory Marker Protein (OMP) is a cytoplasmic protein predominantly expressed in mature olfactory sensory neurons (OSNs) within the olfactory epithelium and olfactory bulb. First identified in the 1980s, OMP is a 19 kDa protein that serves as a hallmark of terminally differentiated OSNs, playing a role in modulating olfactory signal transduction and neuronal maturation. While its exact molecular function remains unclear, studies suggest OMP influences cAMP signaling pathways and interacts with components involved in odorant detection.
OMP antibodies are widely used as selective markers to identify mature OSNs in immunohistochemistry, Western blotting, and immunofluorescence. These antibodies enable researchers to distinguish mature OSNs from immature neuronal precursors or non-neuronal cells, aiding studies on olfactory neurogenesis, neuronal differentiation, and regeneration. OMP's species-specific conservation (e.g., human, mouse, rat) allows cross-species applications in both developmental and pathological contexts.
In research, OMP antibodies have been instrumental in exploring olfactory dysfunction linked to neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) and trauma-induced olfactory loss. They also facilitate the characterization of transgenic models with olfactory system alterations. Commercial OMP antibodies are typically raised against recombinant or peptide antigens, with validation emphasizing specificity to avoid cross-reactivity with unrelated neuronal proteins. Their utility continues to expand in neuroscience, providing insights into olfactory coding, circuit organization, and repair mechanisms.
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