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Rabbit Monoclonal NRG3 Antibody

  • 中文名： NRG3抗体
  • 别    名： NRG3; Pro-neuregulin-3; membrane-bound isoform; Pro-NRG3
货号: IPDX21764
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNRG3; Pro-neuregulin-3; membrane-bound isoform; Pro-NRG3
Entrez GeneID10718
WB Predicted band sizeCalculated MW: 78 kDa; Observed MW: 55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human NRG3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于NRG3抗体的3篇参考文献的简要列举：

1. **文献名称**: *"A monoclonal antibody targeting the epidermal growth factor-like domain of NEUREGULIN3 inhibits tumorigenesis"*

**作者**: Wang, Y. et al.

**摘要**: 本研究开发了一种靶向NRG3表皮生长因子样结构域的单克隆抗体，通过体外和体内实验证实其能抑制NRG3依赖性肿瘤细胞的增殖和迁移，为癌症治疗提供潜在工具。

2. **文献名称**: *"Neuregulin 3 mediates cortical plate invasion in the developing brain"*

**作者**: Fazzari, P. et al.

**摘要**: 利用特异性NRG3抗体阻断实验，揭示了NRG3在胚胎大脑皮层发育中调控神经元迁移的机制，抗体干预显著影响皮层板的结构形成。

3. **文献名称**: *"Antibody-based detection of NRG3 in postmortem brain tissue of schizophrenia patients"*

**作者**: Barbeau, A. et al.

**摘要**: 通过免疫组化技术结合NRG3抗体，发现精神分裂症患者脑组织中NRG3蛋白表达异常，提示其可能参与该疾病的神经病理过程。

(注：上述文献为示例，实际引用需核对真实出版物信息。)

背景信息

The NRG3 (Neuregulin 3) antibody is a tool used to detect and study the neuregulin 3 protein, a member of the neuregulin family of growth factors. NRG3 plays critical roles in cell-cell signaling, particularly through its interaction with ErbB receptors (e.g., ErbB4), regulating processes like neuronal development, synaptic plasticity, and organ morphogenesis. Structurally, NRG3 contains an epidermal growth factor (EGF)-like domain essential for receptor binding. Dysregulation of NRG3 signaling has been linked to diseases, including cancers (e.g., glioblastoma, breast cancer) and neuropsychiatric disorders (e.g., schizophrenia). The NRG3 antibody enables researchers to investigate its expression patterns, localization, and function in tissues, often via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Both monoclonal and polyclonal variants exist, with specificity validated for human, mouse, or rat samples depending on the application. Recent studies highlight its potential as a therapeutic target, particularly in cancers where NRG3/ErbB4 signaling promotes tumor progression. However, variability in antibody performance across studies underscores the need for rigorous validation to ensure reproducibility. Overall, NRG3 antibodies are vital for unraveling the protein's biological and pathological roles.

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