| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nova-1 |
| Entrez GeneID | 4857 |
| WB Predicted band size | Calculated MW: 52 kDa; Observed MW: 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Nova1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是模拟生成的关于Nova1抗体的参考文献示例(仅供参考，非真实文献)：
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1. **文献名称**：*Nova1 regulates cortical neuron apoptosis through RNA splicing and its antibody application in neurodegenerative models*
**作者**：Lee, J., et al.
**摘要**：本研究利用新型Nova1单克隆抗体，探究了Nova1蛋白在调控神经元RNA剪接中的功能，发现其缺失导致小鼠皮层神经元凋亡。抗体通过免疫印迹和免疫组化验证，适用于体外和体内模型。
2. **文献名称**：*Development and validation of a high-affinity Nova1 antibody for human tissue analysis*
**作者**：Garcia, S.M., et al.
**摘要**：报道了一种兔源多克隆抗体的开发，该抗体针对人Nova1蛋白C端结构域，经质谱验证具有高特异性，成功应用于胶质母细胞瘤患者组织的蛋白质定位研究。
3. **文献名称**：*Nova1 antibody cross-reactivity in zebrafish neurodevelopment studies*
**作者**：Chen, H., et al.
**摘要**：评估了哺乳动物Nova1抗体在斑马鱼模型中的交叉反应性，发现其可识别神经发育关键期的同源蛋白，为跨物种比较研究提供了工具支持。
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**建议**：如需真实文献，可通过PubMed或Google Scholar搜索关键词“Nova1 antibody”、“Nova1 immunohistochemistry”或“Nova1 protein function”，并筛选近年高被引论文。Nova1相关研究多集中于神经发育、RNA结合蛋白及癌症领域。
The Nova1 antibody targets the neuro-oncological ventral antigen 1 (NOVA1), a neuron-specific RNA-binding protein first identified in paraneoplastic neurological disorders. Nova1 is primarily expressed in the central nervous system, where it regulates alternative splicing of pre-mRNA, influencing synaptic transmission and neuronal excitability. It plays a critical role in neurodevelopment, neuronal connectivity, and maintaining inhibitory-excitatory balance in neural circuits. Dysregulation of Nova1 has been linked to neurological conditions such as paraneoplastic opsoclonus-myoclonus ataxia (POMA) and neurodevelopmental disorders.
The Nova1 antibody is widely used in neuroscience research to study protein localization, expression patterns, and functional roles in disease models. It enables detection of Nova1 via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial Nova1 antibodies are typically raised in rabbits or mice against specific epitopes of the human or mouse protein, with validation in knockout controls to ensure specificity. Recent studies also explore Nova1's involvement in neurodegenerative diseases and its potential as a biomarker. As a tool, it continues to advance understanding of RNA-mediated mechanisms in neuronal health and disease.
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