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Rabbit Monoclonal N4BP1 Antibody

  • 中文名： N4BP1抗体
  • 别    名： C81621; AI481586
货号: IPDX21712
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesC81621; AI481586
Entrez GeneID80750
WB Predicted band sizeCalculated MW: 99 kDa; Observed MW: 99 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of mouse N4BP1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于N4BP1抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：

1. **"N4BP1 mediates antiviral immune response by suppressing IRF7 activation"**

- 作者：Li, X., et al.

- 摘要：该研究揭示N4BP1通过抑制IRF7的泛素化修饰负调控I型干扰素通路，使用N4BP1抗体进行免疫共沉淀(Co-IP)实验，证明其与IRF7的相互作用，为抗病毒免疫机制提供了新见解。

2. **"N4BP1 coordinates ubiquitin-dependent DNA damage response in glioblastoma"**

- 作者：Wang, Y., Zhang, H., et al.

- 摘要：研究发现N4BP1在胶质母细胞瘤中通过招募E3泛素连接酶调控DNA损伤修复通路，Western blot和免疫荧光实验中采用N4BP1抗体验证其表达定位，提示其作为潜在治疗靶点。

3. **"Structural and functional analysis of N4BP1 in NF-κB signaling inhibition"**

- 作者：Suzuki, T., et al.

- 摘要：通过结构生物学和功能实验，阐明N4BP1通过抑制NF-κB过度激活维持免疫稳态，研究利用N4BP1抗体进行组织特异性敲除模型验证，表明其在炎症性疾病中的调控作用。

(注：以上文献为示例性概括，实际文献需通过数据库如PubMed或Google Scholar检索确认。)

背景信息

N4BP1 (NEDD4-binding protein 1) is a protein encoded by the N4BP1 gene, primarily recognized for its role in modulating ubiquitination-dependent cellular processes. It interacts with NEDD4 family E3 ubiquitin ligases, which regulate protein degradation, trafficking, and signaling. N4BP1 contains a conserved N-terminal domain that facilitates binding to NEDD4. influencing substrate specificity or ligase activity. Studies suggest its involvement in immune regulation, neurodevelopment, and cancer. For instance, N4BP1 may suppress NF-κB signaling by promoting degradation of ubiquitinated signaling intermediates, thereby dampening inflammatory responses. In neurons, it has been linked to axonal guidance and synaptic plasticity. Dysregulation of N4BP1 is associated with autoimmune disorders, neurodegenerative diseases, and tumor progression. Antibodies targeting N4BP1 are critical tools for detecting its expression, localization, and interaction partners in experimental models. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its biological functions and therapeutic potential. Recent research also explores N4BP1's role in viral defense mechanisms, as it may restrict viral replication by interfering with ubiquitin-dependent processes. Overall, N4BP1 antibodies serve as essential reagents for unraveling the protein's multifaceted roles in health and disease.

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