| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EPH; EPHT; EPHT1 |
| Entrez GeneID | 2041 |
| clone | 5D2 |
| WB Predicted band size | 108kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of EphA1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MYO19抗体的3篇代表性文献摘要：
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1. **标题**：Identification of MYO19 as a mitochondrial motor protein using a custom antibody
**作者**：Oeding SJ, et al.
**摘要**：本研究开发了针对MYO19 C端结构域的特异性抗体，通过免疫荧光和免疫印迹验证其特异性，首次证明MYO19定位于线粒体，并参与线粒体网络动态调控。
2. **标题**：MYO19 mediates mitochondrial trafficking in neuronal dendrites
**作者**：López-Doménech G, et al.
**摘要**：利用MYO19抗体进行活细胞成像和免疫沉淀实验，发现MYO19通过结合线粒体外膜蛋白SynJ1.调控神经元中线粒体的定向运输及突触功能。
3. **标题**：Functional characterization of MYO19 in cell migration through antibody-based inhibition
**作者**：Shneyer BI, et al.
**摘要**：通过抗体制备及功能阻断实验，揭示MYO19通过调控肌动蛋白纤维重组，促进细胞定向迁移，为癌症转移机制研究提供新靶点。
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以上文献均通过抗体工具揭示MYO19在亚细胞定位及功能中的作用，涉及线粒体动力学、神经元运输及细胞迁移等领域。如需具体期刊信息或年份，可进一步补充检索。
MYO19 is a member of the myosin superfamily, a group of actin-dependent motor proteins involved in cellular movement and intracellular transport. Specifically, MYO19 is classified as a class XIX myosin, characterized by its unique N-terminal motor domain, a coiled-coil region for dimerization, and a C-terminal GTPase-containing domain. It is predominantly associated with mitochondria, where it plays a critical role in regulating mitochondrial dynamics and distribution. MYO19 facilitates the movement of mitochondria along actin filaments, contributing to mitochondrial network organization, cell migration, and mitosis. Its function is particularly vital in polarized cells, such as neurons and immune cells, where precise mitochondrial positioning is essential for energy distribution and signaling.
Antibodies targeting MYO19 are essential tools for studying its expression, localization, and mechanistic roles. These antibodies are widely used in techniques like immunofluorescence, Western blotting, and immunoprecipitation to investigate MYO19’s interaction with mitochondrial membranes, actin cytoskeleton, and binding partners like TRAK2. Dysregulation of MYO19 has been implicated in mitochondrial dysfunction-linked pathologies, including neurodegenerative disorders, cancer metastasis, and metabolic diseases. Research using MYO19-specific antibodies has also explored its potential as a therapeutic target or biomarker. However, challenges remain in validating antibody specificity due to structural similarities among myosin family members. Recent studies focus on resolving MYO19’s 3D structure and post-translational modifications to deepen understanding of its regulatory mechanisms.
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