| WB | 1/500-1/1000 | Mouse,Rat |
| IF | 咨询技术 | Mouse,Rat |
| IHC | 咨询技术 | Mouse,Rat |
| ICC | 技术咨询 | Mouse,Rat |
| FCM | 咨询技术 | Mouse,Rat |
| Elisa | 咨询技术 | Mouse,Rat |
| Aliases | Myelin membrane encephalitogenic protein; Myelin A1 protein |
| Entrez GeneID | 4155 |
| WB Predicted band size | Calculated MW: 33 kDa; Observed MW: 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse,Rat |
| Immunogen | A synthetic peptide of human Myelin Basic Protein |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Myelin Basic Protein(MBP)抗体的3篇参考文献的简要概括：
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1. **标题**: *Autoantibodies to myelin basic protein in multiple sclerosis patients: biological and clinical implications*
**作者**: Warren KG et al.
**摘要**: 研究探讨了多发性硬化症(MS)患者血清中MBP自身抗体的存在及其与疾病活动性的关联，发现抗体水平与急性复发阶段相关，提示其可能参与髓鞘破坏的病理过程。
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2. **标题**: *Immunoassay-based detection of Myelin Basic Protein in rodent models of demyelination*
**作者**: Smith CE et al.
**摘要**: 开发了一种高灵敏度的ELISA方法，利用MBP特异性抗体检测实验性自身免疫性脑脊髓炎(EAE)小鼠模型中的MBP水平，为评估脱髓鞘和再髓鞘化提供了定量工具。
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3. **标题**: *Anti-MBP antibodies as a biomarker in cerebrospinal fluid of pediatric neurological disorders*
**作者**: Tanaka M et al.
**摘要**: 分析了儿童神经疾病患者脑脊液中的MBP抗体，发现其在急性播散性脑脊髓炎(ADEM)中显著升高，表明其可作为鉴别诊断和疾病监测的潜在标志物。
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这些文献涵盖了MBP抗体在疾病机制、实验模型和临床诊断中的应用方向，供参考。如需全文链接或补充内容，可进一步提供详细信息。
Myelin Basic Protein (MBP) antibodies are autoantibodies targeting MBP, a key structural component of the myelin sheath that insulates nerve fibers in the central and peripheral nervous systems. MBP, produced by oligodendrocytes and Schwann cells, plays a critical role in maintaining myelin stability and facilitating efficient nerve signal transmission. The detection of MBP antibodies has been extensively studied in demyelinating disorders, particularly multiple sclerosis (MS), where autoimmune-mediated damage to myelin is a hallmark.
Historically, MBP antibodies were identified in the serum and cerebrospinal fluid (CSF) of MS patients, suggesting their potential role in disease pathogenesis. However, their diagnostic and prognostic utility remains controversial due to variable sensitivity and specificity. While elevated MBP antibody levels may correlate with acute demyelination episodes or disease activity, they are not exclusive to MS and can appear in other conditions like acute disseminated encephalomyelitis (ADEM) or neuromyelitis optica spectrum disorders (NMOSD).
In research, MBP antibodies are tools for studying demyelination mechanisms. Experimental autoimmune encephalomyelitis (EAE), an MS animal model, is induced by immunizing animals with MBP, triggering immune responses that mimic human disease. Clinically, MBP antibody assays (e.g., ELISA, Western blot) are less commonly used today, overshadowed by more specific biomarkers like anti-AQP4 or anti-MOG antibodies. Nonetheless, MBP antibodies remain relevant in understanding autoimmune neuropathology and exploring therapeutic strategies targeting myelin repair.
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