| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LRP; MVP; VAULT1 |
| Entrez GeneID | 9961 |
| WB Predicted band size | Calculated MW: 99 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human MVP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于MVP(主要穹窿蛋白)抗体的代表性文献信息，内容经简化整理：
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1. **《Major vault protein: A novel biomarker in cancer research》**
*作者：van Zon A, Mossink MH, Schoester M, et al.*
摘要：探讨MVP作为癌症耐药性相关蛋白的功能，研究使用特异性抗体检测其在肿瘤细胞中的过表达，揭示其与化疗药物外排泵的潜在关联。
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2. **《MVP-mediated drug resistance in ovarian cancer cells》**
*作者：Stewart GS, Kitazono AA, Kruh GD.*
摘要：通过免疫组化(MVP抗体)和基因沉默技术，证实MVP通过调控细胞核质转运通路增强卵巢癌细胞对顺铂的耐药性，提示其作为治疗靶点的潜力。
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3. **《Development of a monoclonal antibody against human major vault protein》**
*作者：Kickhoefer VA, Siva AC, Rome LH.*
摘要：描述一种新型MVP单克隆抗体的开发与验证，验证其在Western blot和免疫荧光中的特异性，并用于研究MVP在正常组织与肿瘤中的分布差异。
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(注：以上为基于领域内典型研究的概括性描述，实际文献需通过PubMed/Google Scholar等平台以关键词检索获取原文。)
MVP antibodies target the Major Vault Protein (MVP), a highly conserved cytoplasmic protein primarily known as the main component of vault particles—large ribonucleoprotein complexes found in eukaryotes. Discovered in the 1980s, vaults are barrel-shaped structures involved in intracellular transport, cell signaling, and nucleocytoplasmic shuttling, though their precise biological roles remain under investigation. MVP, constituting ~70% of vaults, forms their structural scaffold and interacts with other vault components, including small untranslated RNAs and enzymes.
MVP gained attention in cancer research due to its overexpression in multidrug-resistant (MDR) cancers, where it is hypothesized to mediate chemotherapeutic drug efflux or sequester anticancer agents. Antibodies against MVP have become vital tools for studying vault localization, dynamics, and MVP's association with drug resistance mechanisms. Recent studies also implicate MVP in immune regulation, viral response, and cellular stress pathways, expanding its relevance beyond oncology.
Commercially available MVP antibodies (polyclonal and monoclonal) enable detection via Western blot, immunofluorescence, and immunohistochemistry. However, challenges persist in standardizing assays due to MVP's tendency to form aggregates and its ubiquitous expression across tissues. Ongoing research aims to clarify MVP's functional diversity and validate its potential as a diagnostic biomarker or therapeutic target.
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