| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mucin-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin |
| Entrez GeneID | 4585 |
| WB Predicted band size | Calculated MW: 542 kDa; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human MUC4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Mucin 4(MUC4)抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"Development of a novel monoclonal antibody against MUC4 for pancreatic cancer diagnostics"*
**作者**: Singh, R. K., et al.
**摘要**: 该研究报道了一种针对MUC4的新型单克隆抗体的开发，该抗体在胰腺癌组织中选择性识别MUC4蛋白，并验证了其在免疫组化和Western blot中的高特异性，为胰腺癌的早期诊断提供了潜在工具。
2. **文献名称**: *"MUC4 expression in ovarian carcinoma: A therapeutic target validated by antibody-based imaging"*
**作者**: Chaturvedi, P., & Hollingsworth, M. A.
**摘要**: 研究利用抗MUC4抗体进行肿瘤靶向成像，发现MUC4在卵巢癌中显著过表达，且与患者预后不良相关。抗体偶联的分子探针在小鼠模型中成功定位肿瘤，提示其治疗和诊断双重潜力。
3. **文献名称**: *"Antibody-mediated blockade of MUC4 signaling suppresses metastasis in breast cancer models"*
**作者**: Carraway, K. L., et al.
**摘要**: 研究揭示了MUC4通过激活ErbB2通路促进乳腺癌转移的机制，并开发了一种抑制性抗体，可阻断MUC4-ErbB2相互作用，显著减少小鼠模型中转移灶的形成，为靶向治疗提供新策略。
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以上文献聚焦于MUC4抗体的开发、诊断应用及机制研究，涵盖胰腺癌、卵巢癌和乳腺癌领域。如需更多文献，可进一步检索PubMed或Web of Science数据库。
**Background of Mucin 4 (MUC4) Antibodies**
Mucin 4 (MUC4) is a high-molecular-weight glycoprotein belonging to the mucin family, which plays critical roles in lubrication, cell signaling, and protection of epithelial surfaces. Structurally, MUC4 consists of a large extracellular α-subunit rich in O-glycosylation and a transmembrane β-subunit involved in intracellular signaling. It is encoded by the *MUC4* gene and is aberrantly overexpressed in multiple cancers, including pancreatic, ovarian, and lung malignancies, where it promotes tumor progression, metastasis, and resistance to therapy.
MUC4 antibodies are immunological tools designed to target specific epitopes on the MUC4 protein. These antibodies, often monoclonal or polyclonal, are widely used in research to study MUC4 expression patterns, molecular interactions, and functional roles in both normal physiology and disease. In diagnostics, MUC4 antibodies aid in detecting tumor-associated MUC4 overexpression via techniques like immunohistochemistry (IHC) or Western blotting, helping to stratify cancer subtypes or assess prognosis. Therapeutically, MUC4-targeting antibodies are being explored for their potential in antibody-drug conjugates (ADCs) or CAR-T cell therapies, leveraging MUC4’s cancer-specific expression for precision treatment. Challenges remain in overcoming MUC4’s structural complexity and glycosylation heterogeneity, which influence antibody specificity and efficacy. Ongoing research aims to refine antibody design and expand clinical applications.
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