| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MASK; MST4 |
| Entrez GeneID | 51765 |
| WB Predicted band size | Calculated MW: 47 kDa; Observed MW: 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human MST4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MST4抗体的3篇参考文献示例(内容基于模拟文献，仅供参考)：
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1. **文献名称**：*MST4 Kinase Regulates Epithelial Cell Polarization via ERM Proteins*
**作者**：Lin, Y. et al.
**摘要**：本研究利用特异性MST4抗体进行免疫共沉淀和免疫荧光分析，发现MST4通过磷酸化Ezrin/Radixin/Moesin(ERM)蛋白调控上皮细胞极性和细胞骨架重组，揭示了其在细胞形态维持中的关键作用。
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2. **文献名称**：*Development of a Polyclonal Antibody Against Human MST4 and Its Application in Cancer Biomarker Screening*
**作者**：Zhang, R. et al.
**摘要**：研究团队制备了兔源多克隆MST4抗体，并通过Western blot和免疫组化验证其特异性。该抗体成功应用于多种癌症组织检测，表明MST4在结直肠癌中高表达且与患者生存率负相关。
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3. **文献名称**：*MST4 Modulates Autophagy via Interaction with LC3 in Response to Nutrient Stress*
**作者**：Chen, L. et al.
**摘要**：通过MST4抗体介导的敲低实验和共定位分析，本文证明MST4与自噬标记蛋白LC3结合，参与调控营养缺乏条件下的自噬启动，为代谢应激反应机制提供了新见解。
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(注：以上文献为模拟示例，实际引用需以真实出版物为准。)
The MST4 antibody is a tool used to study the mammalian Ste20-like kinase 4 (MST4), a serine/threonine kinase belonging to the STE20 family. MST4. encoded by the *STK26* gene, plays critical roles in regulating cellular processes such as cell polarity, proliferation, apoptosis, and stress responses. It is involved in signaling pathways like the Hippo pathway and MAPK cascade, impacting organ size control, tissue homeostasis, and cancer progression. MST4 interacts with scaffolding proteins, including STRIPAK complexes, to modulate its activity and localization, particularly at the Golgi apparatus and cell-cell junctions.
Research highlights MST4's dual role in cancer: it can act as a tumor suppressor by promoting apoptosis or as an oncogene by enhancing cell migration and survival, depending on cellular context. Dysregulation of MST4 has been linked to cancers, including colorectal carcinoma and glioblastoma. The MST4 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MST4 expression, subcellular localization, and interaction partners. Its applications span studies in cell biology, cancer research, and developmental biology, aiding in elucidating MST4's regulatory mechanisms and therapeutic potential. Commercial MST4 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat samples.
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