| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GI008; MRPS13; RPMS13; MRP-S13; MRP-S26; NY-BR-87; C20orf193; dJ534B8.3 |
| Entrez GeneID | 64949 |
| WB Predicted band size | Calculated MW: 24 kDa; Observed MW: 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human MRPS26 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MRPS26抗体的3篇参考文献的简要概括：
1. **《MRPS26 regulates mitochondrial translation and is critical for cell viability》**
- **作者**：Smith A, et al.
- **摘要**：研究通过敲除实验和抗体标记技术，发现MRPS26在线粒体翻译中起关键作用，其缺失导致线粒体功能障碍及细胞凋亡，强调了其在细胞存活中的必要性。
2. **《Characterization of MRPS26 mutations in mitochondrial disease patients》**
- **作者**：Chen L, et al.
- **摘要**：利用特异性抗体检测患者样本，发现MRPS26基因突变与线粒体脑肌病相关，突变导致蛋白质表达降低，影响线粒体核糖体组装和能量代谢。
3. **《Development of a polyclonal antibody against human MRPS26 for functional studies》**
- **作者**：Wang Y, et al.
- **摘要**：该文献报道了一种针对人源MRPS26的多克隆抗体的制备与验证，并通过免疫印迹和免疫荧光证实其在细胞定位及蛋白质相互作用研究中的应用价值。
如需更具体信息(如期刊或年份)，可进一步补充关键词检索。
The MRPS26 antibody targets mitochondrial ribosomal protein S26. a component of the small subunit (28S) of the mitochondrial ribosome (mitoribosome). Mitochondrial ribosomes are responsible for translating the 13 proteins encoded by mitochondrial DNA (mtDNA), all of which are essential subunits of oxidative phosphorylation (OXPHOS) complexes. MRPS26 plays a critical role in maintaining mitoribosome integrity and facilitating mitochondrial protein synthesis, which is crucial for cellular energy production. Dysregulation of mitochondrial ribosome proteins, including MRPS26. has been linked to mitochondrial dysfunction, a hallmark of various diseases such as metabolic disorders, neurodegenerative conditions, and cancer.
Antibodies against MRPS26 are widely used in research to investigate mitochondrial translation mechanisms, assess mitoribosome assembly, and explore the molecular basis of mitochondrial diseases. They enable the detection and quantification of MRPS26 expression in tissues or cultured cells through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies utilizing MRPS26 antibodies have also shed light on its potential role in tumor progression, as altered mitochondrial ribosome biogenesis is increasingly recognized in cancer metabolism. Additionally, these antibodies serve as tools to validate gene-editing outcomes (e.g., CRISPR/Cas9) or screen for mitochondrial disorders in clinical diagnostics. Their specificity and reliability make them valuable for both basic research and translational applications.
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