| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAOA; Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A |
| Entrez GeneID | 4128 |
| WB Predicted band size | Calculated MW: 60 kDa; Observed MW: 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Monoamine Oxidase A |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与Monoamine Oxidase A(MAO-A)抗体相关的文献概览，涵盖抗体特异性验证及生物学研究应用：
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1. **文献名称**：*"Monoamine oxidase A enzyme and antibody distribution in human cerebral cortex: implications for Alzheimer’s disease"*
**作者**：Gulyás B. et al.
**摘要**：通过免疫组化和Western blot验证MAO-A抗体在人脑皮层中的特异性，发现其在阿尔茨海默病患者前额叶皮质中表达升高，并与淀粉样斑块共定位，提示其参与神经退行性病理过程。
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2. **文献名称**：*"Characterization of a monoclonal antibody to human monoamine oxidase A"*
**作者**：Denney R.M. et al.
**摘要**：报道一种高特异性抗MAO-A单克隆抗体的开发，通过ELISA和免疫印迹验证其仅识别MAO-A而非MAO-B，成功应用于血小板和神经元组织样本的定量分析，支持其在神经精神疾病研究中的实用性。
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3. **文献名称**：*"Aggressive behavior and altered monoamine oxidase A levels in a novel genetic mouse model"*
**作者**：Cases O. et al.
**摘要**：利用MAO-A抗体研究基因敲除小鼠模型，发现MAO-A蛋白缺失导致前额叶皮质5-HT水平异常升高，与攻击行为相关，抗体特异性通过基因型-表型关联分析确认。
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4. **文献名称**：*"Selective increase of monoamine oxidase A in prefrontal cortex of violent suicide attempters"*
**作者**：Oreland L. et al.
**摘要**：通过免疫组织化学结合MAO-A抗体，发现自杀倾向者的前额叶皮质MAO-A表达显著高于对照组，提示其与情绪调节和冲动行为的分子关联，抗体特异性经阴性对照实验验证。
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这些文献展示了MAO-A抗体在疾病机制、行为学及分子诊断中的应用，均包含抗体验证的关键实验(如Western blot、免疫组化、基因模型对照)。如需具体期刊或年份信息可进一步补充。
Monoamine Oxidase A (MAO-A) is a mitochondrial enzyme critical for metabolizing monoamine neurotransmitters, including serotonin, norepinephrine, and dopamine, regulating mood, cognition, and behavior. MAO-A antibodies are immunodetection tools targeting this enzyme, widely used in research to study its expression, localization, and function in neurological and psychiatric disorders. These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping map MAO-A distribution in brain regions linked to depression, anxiety, and aggression. They also aid in investigating MAO-A's role in cancer progression, as elevated levels are observed in certain tumors.
MAO-A antibodies must distinguish between MAO-A and its isoform MAO-B, which shares structural similarities but differs in substrate preference and tissue distribution. Specificity validation via knockout controls or peptide blocking is essential. Research using these antibodies has elucidated MAO-A's involvement in gene-environment interactions, such as the MAOA-LPR polymorphism's association with stress-sensitive behaviors. Additionally, they support drug development, particularly for MAO inhibitors used in treating depression and Parkinson's disease. Understanding MAO-A's dynamics through antibody-based studies remains pivotal for unraveling its pathophysiological roles and therapeutic potential.
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