| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1 |
| Entrez GeneID | 4314 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human MMP3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于MMP3抗体的参考文献示例(注：部分文献信息为虚构，仅用于示例格式)：
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1. **文献名称**：*Monoclonal Antibody Targeting MMP3 Suppresses Tumor Invasion in Colorectal Cancer Models*
**作者**：Smith, J. et al.
**摘要**：该研究开发了一种靶向MMP3的单克隆抗体，通过体外和体内实验证明其可有效抑制结直肠癌细胞的侵袭和迁移，并降低肿瘤微环境中MMP3的酶活性。
2. **文献名称**：*Characterization of a Novel Polyclonal MMP3 Antibody for Immunohistochemical Applications*
**作者**：Li, X. & Wang, H.
**摘要**：文章报道了一种新型多克隆MMP3抗体的开发与验证，通过Western blot和免疫组化实验证实其高特异性，适用于人类组织样本中MMP3蛋白表达的定位与定量分析。
3. **文献名称**：*MMP3 Neutralizing Antibody Attenuates Osteoarthritis Progression in a Mouse Model*
**作者**：Chen, R. et al.
**摘要**：研究利用中和性MMP3抗体干预骨关节炎小鼠模型，结果显示抗体治疗显著减少软骨降解和炎症因子释放，为MMP3在骨关节病中的治疗潜力提供依据。
4. **文献名称**：*A Cross-Reactive MMP3 Antibody Reveals Evolutionary Conservation of Protease Domains*
**作者**：Kumar, S. & Patel, V.
**摘要**：通过比较不同物种MMP3的结构，发现其催化结构域高度保守，并验证了一种可识别人类和小鼠MMP3的交叉反应性抗体，为跨物种研究提供工具。
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如需真实文献，建议通过PubMed或Google Scholar以“MMP3 antibody”+应用方向(如cancer、osteoarthritis)为关键词检索。
Matrix metalloproteinase 3 (MMP3), also known as stromelysin-1. is a zinc-dependent endopeptidase involved in extracellular matrix (ECM) remodeling, wound healing, and tissue repair. It plays a key role in degrading components like collagen, fibronectin, and proteoglycans, and activates other MMPs, amplifying proteolytic cascades. Dysregulated MMP3 expression is linked to pathological conditions, including arthritis, cardiovascular diseases, and cancer metastasis.
MMP3 antibodies are essential tools for detecting and quantifying MMP3 levels in research and diagnostics. They enable the study of MMP3's role in ECM dynamics, inflammation, and disease progression through techniques like Western blotting, immunohistochemistry, and ELISA. Specific monoclonal or polyclonal antibodies target distinct epitopes, allowing differentiation between pro-MMP3 (inactive zymogen) and active MMP3. Some antibodies inhibit enzymatic activity, aiding functional studies.
In clinical contexts, MMP3 antibodies help assess disease severity (e.g., rheumatoid arthritis) or monitor therapeutic responses. Challenges include ensuring specificity due to structural similarities among MMP family members. Advances in antibody engineering continue to improve sensitivity and application versatility, supporting both mechanistic research and biomarker development.
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