| WB | 1/500-1/1000 | Human,Rat,Hamster |
| IF | 咨询技术 | Human,Rat,Hamster |
| IHC | 咨询技术 | Human,Rat,Hamster |
| ICC | 技术咨询 | Human,Rat,Hamster |
| FCM | 咨询技术 | Human,Rat,Hamster |
| Elisa | 咨询技术 | Human,Rat,Hamster |
| Aliases | BA2R; CCG1; CCGS; DYT3; N TAF1; NSCL2; p250; TAF1; TAF2A; TAFII250; XDP;;TAF1 |
| WB Predicted band size | Calculated MW: 213 kDa ; Observed MW: 300 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TAF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MMP26抗体的3篇参考文献的简要信息：
1. **文献名称**：*"Monoclonal antibody against MMP-26 (matrilysin-2): characterization and potential diagnostic application"*
**作者**：Maruyama M, et al.
**摘要**：该研究报道了一种新型抗MMP26单克隆抗体的开发与表征，验证了其在人组织样本中的特异性，并探讨了其在癌症诊断中的潜在应用，尤其在子宫内膜癌中的表达分析。
2. **文献名称**：*"MMP-26 expression in human prostate cancer: a novel biomarker detected by immunohistochemistry using tissue microarray"*
**作者**：Zhao Y, et al.
**摘要**：研究利用MMP26抗体通过免疫组化技术检测前列腺癌组织芯片，发现MMP26在肿瘤侵袭区域的过表达，提示其可能作为癌症进展的生物标志物。
3. **文献名称**：*"A novel antibody-based approach to detect MMP-26 activity in biological fluids"*
**作者**：Kolkova K, et al.
**摘要**：该文献描述了一种基于抗体的ELISA方法，用于定量检测体液中的MMP26活性，并验证其在炎症性疾病模型中的敏感性及特异性。
*注：上述文献信息为示例性质，实际引用需核对具体数据库(如PubMed)的原文信息。若需全文链接或更多细节，建议通过学术平台检索相关关键词。*
**Background of MMP26 Antibodies**
Matrix metalloproteinase 26 (MMP26), also known as matrilysin-2 or endometase, is a member of the zinc-dependent MMP family involved in extracellular matrix (ECM) remodeling. Unlike many MMPs, MMP26 exhibits a unique domain structure, lacking a hemopexin-like domain, and is expressed in specific tissues, including the endometrium, placenta, and certain cancers. It plays roles in physiological processes like tissue repair and pathological conditions such as tumor progression, angiogenesis, and metastasis.
MMP26 antibodies are immunological tools designed to detect, quantify, or inhibit MMP26 in research and diagnostic contexts. Polyclonal and monoclonal antibodies target specific epitopes of MMP26. enabling applications in immunohistochemistry (IHC), Western blotting, ELISA, and functional studies. These antibodies help elucidate MMP26's expression patterns, regulation, and interactions with substrates (e.g., collagen IV, α1-proteinase inhibitor) or inhibitors (e.g., TIMPs).
Research using MMP26 antibodies has revealed its upregulated expression in cancers (e.g., endometrial, prostate, lung), linking it to tumor invasiveness and poor prognosis. However, challenges persist, including antibody specificity issues due to homology with other MMPs and variability in post-translational modifications. Validating antibody reliability through techniques like siRNA knockdown or recombinant protein controls is critical. Continued development of high-affinity, isoform-specific MMP26 antibodies remains essential for advancing its study as a potential biomarker or therapeutic target in diseases.
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