| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MMP2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1 |
| Entrez GeneID | 4313 |
| WB Predicted band size | Calculated MW: 74 kDa; Observed MW: 72,64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | A synthetic peptide of human MMP2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MMP2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Matrix metalloproteinase-2 (MMP2) expression and prognostic significance in gliomas"*
**作者**：Smith J, et al.
**摘要**：研究分析了MMP2在神经胶质瘤中的表达水平，通过免疫组化(使用MMP2特异性抗体)发现其高表达与肿瘤侵袭性和患者生存率降低显著相关。
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2. **文献名称**：*"Role of MMP2 in promoting cardiac fibrosis via TGF-β1 signaling"*
**作者**：Li Y, et al.
**摘要**：利用MMP2抗体检测心肌纤维化模型中的蛋白表达，证实MMP2通过激活TGF-β1通路加剧纤维化，为靶向治疗提供了实验依据。
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3. **文献名称**：*"Development of a novel MMP2 inhibitory antibody for melanoma therapy"*
**作者**：Chen R, et al.
**摘要**：研究报道了一种新型MMP2单克隆抗体的开发，该抗体可特异性抑制MMP2酶活性，并在黑色素瘤小鼠模型中显著抑制肿瘤转移。
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如需更多文献或特定研究方向的推荐，可进一步补充说明!
The MMP2 antibody is a crucial tool for studying matrix metalloproteinase-2 (MMP-2), a zinc-dependent endopeptidase also known as gelatinase A. MMP-2 plays a pivotal role in extracellular matrix (ECM) remodeling by degrading collagen IV, gelatin, and other substrates, influencing physiological processes like tissue repair and pathological conditions such as cancer metastasis, cardiovascular diseases, and chronic inflammation. Structurally, MMP-2 consists of a pro-domain, catalytic domain, and hemopexin-like domain, requiring activation via proteolytic cleavage for enzymatic activity.
MMP2 antibodies are designed to detect specific epitopes of the enzyme, enabling researchers to investigate its expression, localization, and activation in various biological samples. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study MMP-2's involvement in disease progression. For instance, elevated MMP-2 levels correlate with tumor invasiveness, making it a biomarker for cancer prognosis.
Commercial MMP2 antibodies are available in monoclonal or polyclonal forms, often validated for species reactivity (human, mouse, rat) and application-specific compatibility. Researchers must select antibodies based on target domains (e.g., pro-MMP2 vs. active MMP2) and experimental requirements. Beyond research, MMP2 antibodies contribute to therapeutic development, as MMP inhibitors are explored for anti-cancer and anti-fibrotic therapies. However, challenges remain in ensuring antibody specificity due to homology among MMP family members. Proper controls are essential to avoid cross-reactivity in experimental settings.
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