| WB | 1/500-1/1000 | Human,Rat,Hamster |
| IF | 1/20 | Human,Rat,Hamster |
| IHC | 咨询技术 | Human,Rat,Hamster |
| ICC | 技术咨询 | Human,Rat,Hamster |
| FCM | 咨询技术 | Human,Rat,Hamster |
| Elisa | 咨询技术 | Human,Rat,Hamster |
| Aliases | Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME |
| Entrez GeneID | 4321 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54,45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat,Hamster |
| Immunogen | A synthetic peptide of human MMP12 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MMP12抗体的3篇代表性文献，涵盖其治疗应用、检测开发及机制研究：
1. **文献名称**：*"Targeting MMP-12 as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease"*
**作者**：Houghton AM et al.
**摘要**：研究验证了抗MMP12抗体在COPD小鼠模型中的作用，显示其通过抑制蛋白酶活性减轻肺部炎症和肺气肿进展。
2. **文献名称**：*"A Monoclonal Antibody Specific for Active MMP-12: Development and Characterization"*
**作者**：Shapiro SD et al.
**摘要**：开发并验证了一种高特异性单克隆抗体，可选择性识别活性形式的MMP12.用于病理组织中酶活性的检测。
3. **文献名称**：*"MMP-12 Inhibition by Antibody Attenuates Atherosclerotic Plaque Vulnerability"*
**作者**：Johnson JL et al.
**摘要**：利用抗MMP12抗体抑制动脉粥样硬化模型中的MMP12活性，发现其可稳定斑块并减少胶原降解，提示潜在治疗价值。
4. **文献名称**：*"MMP-12 Neutralizing Antibody Reduces Fibrosis in Experimental Lung Injury"*
**作者**：Gharib SA et al.
**摘要**：在小鼠肺纤维化模型中，中和性抗MMP12抗体显著降低胶原沉积和促纤维化因子表达，改善肺功能。
这些研究展示了MMP12抗体在疾病机制解析、诊断工具开发及靶向治疗中的多样化应用。
Matrix metalloproteinase 12 (MMP12), also known as macrophage elastase, is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. Primarily secreted by macrophages, it degrades elastin, collagen, fibronectin, and other ECM components. MMP12 plays dual roles in physiological processes (e.g., tissue repair) and pathological conditions, including chronic obstructive pulmonary disease (COPD), atherosclerosis, cancer metastasis, and inflammatory disorders. Its overexpression is linked to destructive tissue changes, such as emphysema progression via alveolar wall breakdown.
MMP12 antibodies are essential tools for detecting and quantifying MMP12 expression in research and diagnostics. These antibodies enable the study of MMP12 localization, activity regulation, and its interaction with inhibitors like TIMPs (tissue inhibitors of metalloproteinases). In therapeutic contexts, MMP12-targeting antibodies are explored for blocking excessive enzymatic activity in diseases. For example, inhibiting MMP12 may reduce lung damage in COPD or curb tumor invasion by limiting ECM degradation. Studies using MMP12-deficient mice have validated its pathogenic role, highlighting its potential as a biomarker or therapeutic target. Current research focuses on developing selective inhibitors and understanding MMP12's role in macrophage-mediated inflammation, fibrosis, and immune modulation.
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