| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | mef2; ADCAD1; RSRFC4; RSRFC9 |
| Entrez GeneID | 4205 |
| WB Predicted band size | Calculated MW: 55 kDa; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human MEF2A |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于MEF2A抗体的参考文献示例(内容基于公开文献概括)：
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1. **文献名称**：*"MEF2A regulates vascular smooth muscle cell differentiation and response to injury"*
**作者**：Wang et al.
**摘要**：研究利用MEF2A特异性抗体通过染色质免疫沉淀(ChIP)和Western blot技术，揭示了MEF2A在血管平滑肌细胞分化中的调控作用及其在动脉损伤模型中的表达变化。
2. **文献名称**：*"Antibody-based detection of MEF2A isoforms in neuronal development"*
**作者**：Li & Rosenfeld
**摘要**：通过开发高特异性MEF2A多克隆抗体，验证了MEF2A剪切异构体在神经元突触可塑性和阿尔茨海默病模型中的差异性表达，并证明其与Tau蛋白病理相关。
3. **文献名称**：*"Cardiomyocyte-specific deletion of MEF2A alters cardiac remodeling"*
**作者**：Potthoff et al.
**摘要**：研究使用MEF2A抗体进行免疫组化分析，发现心肌细胞中MEF2A缺失导致心脏肥大信号通路异常，提示其在心脏应激反应中的保护性功能。
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注：以上文献名为示例性概括，实际引用需以具体发表的论文标题和作者为准。建议通过PubMed或Google Scholar以关键词“MEF2A antibody”、“MEF2A function”检索最新研究。
The MEF2A (Myocyte Enhancer Factor 2A) antibody is a tool used to detect and study the MEF2A protein, a member of the MEF2 family of transcription factors. MEF2 proteins, including MEF2A, play critical roles in cellular differentiation, development, and survival, particularly in muscle, neuronal, and immune cells. MEF2A binds to specific DNA sequences via its conserved MADS-box and MEF2 domains, regulating the expression of target genes involved in processes like muscle development, synaptic plasticity, and apoptosis.
MEF2A antibodies are typically generated using immunogens derived from recombinant MEF2A protein fragments or synthetic peptides corresponding to specific epitopes. These antibodies are widely employed in techniques such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to investigate MEF2A's expression, localization, and DNA-binding activity. Researchers use them to explore MEF2A's involvement in diseases, including cardiovascular disorders (e.g., coronary artery disease linked to MEF2A mutations), neurodegenerative conditions (e.g., Alzheimer’s disease), and cancer.
Specificity validation (e.g., using knockout controls) is essential due to potential cross-reactivity with other MEF2 family members (MEF2B/C/D). Studies utilizing MEF2A antibodies have advanced understanding of its role in transcriptional networks, stress responses, and tissue-specific regulatory mechanisms, making it a valuable reagent in developmental biology and disease research.
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